{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:33:58Z","timestamp":1773419638531,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little progress has been made in determining prognostic factors for patients with high\u2010grade mature B\u2010cell non\u2010Hodgkin lymphoma (HG B\u2010NHL). Based on the important role of lymphocytes in cancer progression, this study aimed to explore the effect of peripheral blood lymphocytes on the prognosis of pediatric HG B\u2010NHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged less than 18\u00a0years with newly diagnosed HG B\u2010NHL were enrolled. Peripheral blood lymphocyte subset levels were detected at diagnosis, and their optimal cutoff values were determined according to event\u2010free survival (EFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 206 patients were enrolled. The 5\u2010year EFS and overall survival (OS) rates of the whole group were 92.1% \u00b1 1.9% and 96.6% \u00b1 1.3%, respectively. The 5\u2010year EFS rate was worse in patients with a low relative CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell count (87.2% vs. 97.0%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008), high relative CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell count (79.1% vs. 93.4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), low CD4\/CD8 ratio (80.5% vs. 94.2%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), and low B\u2010cell count (80.0% vs. 93.4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02) at diagnosis than their counterparts. Cox multivariate analysis identified low relative CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell (HR = 4.91) and B\u2010cell (HR = 3.87) counts at diagnosis as independent adverse prognostic factors. Patients with simultaneously low levels of CD4\n                      <jats:sup>+<\/jats:sup>\n                      T and B cells had the worst outcomes in the entire cohort, with a 5\u2010year EFS rate of 60.0%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Low relative CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell and B\u2010cell counts at diagnosis are associated with poor prognosis in children and adolescents with HG B\u2010NHL in the real world.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31613","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T08:49:50Z","timestamp":1740041390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Peripheral Blood Lymphocyte Subsets in Children and Adolescents With High\u2010Grade Mature B\u2010Cell Non\u2010Hodgkin Lymphoma: A Real\u2010World Outcomes Study"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-6031","authenticated-orcid":false,"given":"Chenggong","family":"Zeng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Pediatric Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqing","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Pediatric Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-5837","authenticated-orcid":false,"given":"Junting","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Pediatric Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-0526","authenticated-orcid":false,"given":"Jia","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Pediatric Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-8853","authenticated-orcid":false,"given":"Feifei","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Pediatric Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou 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