{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:33:46Z","timestamp":1773419626362,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report the case of a 50\u2010day\u2010old infant with a nasopharyngeal mass causing respiratory distress at birth. Imaging revealed a mass from the clivus and features indicative of tuberous sclerosis complex (TSC), including cortical tubers and subependymal nodules. The mass was surgically excised, with histopathology confirming chordoma. Genetic analysis identified pathogenic mutation in TSC2 gene. Postsurgery, he had residual disease and was treated with mammalian target of rapamycin (mTOR) inhibitor sirolimus, leading to complete resolution. This case is notable as it represents the first instance of mTOR inhibitor use resulting in complete resolution of TSC\u2010associated chordoma, suggesting potential for further research into mTOR therapy for chordomas.<\/jats:p>","DOI":"10.1002\/pbc.31632","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:46:31Z","timestamp":1741715191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clival Chordoma Presenting as Airway Obstruction in a Neonate With Tuberous Sclerosis and Good Response to sirolimus"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2130-8269","authenticated-orcid":false,"given":"Aastha","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Medical Oncology All India Institute of Medical Sciences  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakansha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Endocrinology All India Institute of Medical Sciences  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-3083","authenticated-orcid":false,"given":"Sameer","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology All India Institute of Medical Sciences  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aman","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology All India Institute of Medical Sciences  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adarsh","family":"Barwad","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology All India Institute of Medical Sciences  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03511-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0258-RA"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008947301735"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not228"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.085092"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.08.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2017.01.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb37754.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S90262"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70337-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015912804499537"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00030"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-2317"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-022-05749-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.14245\/kjs.2015.12.3.230"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpr.2022.300624"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.10525"}],"container-title":["Pediatric Blood &amp; 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