{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T05:08:26Z","timestamp":1775452106573,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Information about pediatric lymphoblastic lymphoma (LLy) in low\u2010 and middle\u2010income countries is scarce. Thus, here we describe the clinical characteristics, treatment, and outcome of a large cohort of children and adolescents with LLy in Latin America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted of pediatric patients with LLy treated at 10 institutions (2007\u20132017) that are members of the St. Jude Global Alliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 126 patients were included: 60 (47.6%) had T\u2010cell LLy, 49 (38.9%) had precursor B\u2010cell LLy, and 17 (13.5%) had LLy with an unknown immunophenotype. Ninety\u2010seven (77%) presented with stage III\/IV disease, and 42 (33.3%) had complications at diagnosis. In 30 (23.8%) cases, the pathology diagnosis was received more than 15 days after the biopsy, and in 23 (18.2%) cases, a pathology review at another institution was required. The 5\u2010year event\u2010free survival and overall survival were 73% and 78%, respectively. Abandonment\u2010sensitive event\u2010free survival and overall survival were 65% and 70%, respectively. Events included disease relapse\/progression (<jats:italic>n<\/jats:italic> = 22), refractory disease (<jats:italic>n<\/jats:italic> = 1), treatment abandonment (<jats:italic>n<\/jats:italic> = 11), death during induction (<jats:italic>n<\/jats:italic> = 4), death during complete remission (<jats:italic>n<\/jats:italic> = 4), and second malignancy (<jats:italic>n<\/jats:italic> = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diagnosis of pediatric LLy in Latin America was challenging; however, the proportions of T\u2010cell and precursor B\u2010cell immunophenotypes were balanced. Most patients presented with high\u2010risk disease, and many had critical conditions, leading to a relatively high toxic death rate. Improvements in diagnosis, supportive measures, and follow\u2010up are imperative to decrease treatment abandonment and improve the outcomes of pediatric patients with LLy in Latin America.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31674","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T01:36:39Z","timestamp":1743471399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Retrospective Cohort Analysis of Children and Adolescents With Lymphoblastic Lymphoma in Latin America"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8723-1239","authenticated-orcid":false,"given":"Magdalena","family":"Schelotto","sequence":"first","affiliation":[{"name":"Hospital Pereira Rossell, Fundaci\u00f3n P\u00e9rez Scremini  Montevideo 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Jose Renan Esquivel  Panama City Panam\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Hospital Escuela  Tegucigalpa Honduras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godwin","family":"Job","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilmarie","family":"Muniz\u2010Talavera","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor M.","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Jeha","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika L.","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee 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