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This study looked at using peak\u2010post\u2010first\u2010enoxaparin\u2010dose anti\u2010Xa to guide subsequent enoxaparin dose and timing of administration in children deemed high\u2010thrombotic risk. Fourteen patients (seven aged\u00a0&lt;3\u00a0months, seven children\/adolescents) were identified and reviewed retrospectively. All patients were commenced on a therapeutic enoxaparin dose within \u226420\u00a0h with average time to therapeutic anti\u2010Xa of 15.4\u00a0h (range 4\u201334\u00a0h) for neonates\/infants and 10.8\u00a0h (range 4\u201324\u00a0h) for children\/adolescents. No patient had supratherapeutic anti\u2010Xa or thrombotic\/bleeding events. Further studies are needed to validate this approach.<\/jats:p>","DOI":"10.1002\/pbc.31691","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T09:09:51Z","timestamp":1743844191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Enoxaparin Adjustment for Childhood Thrombosis\/Thromboprophylaxis"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-4456","authenticated-orcid":false,"given":"Joel","family":"Livingston","sequence":"first","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"},{"name":"The Women's &amp; Children's Health Research Institute  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-6696","authenticated-orcid":false,"given":"Leanne","family":"Meakins","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-017X","authenticated-orcid":false,"given":"Aisha","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Stammers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Corriveau\u2010Bourque","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Serebrin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Bauman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Alberta  Edmonton Alberta Canada"},{"name":"KidClot Program Stollery Children's Hospital Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001847"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049\u20103848(89)90237\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049\u20103848(88)90125\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(00)90005\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11\u20102308"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024786"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2018.06.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551\u20106776\u201025.8.689"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2010.08163.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.11.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.9.1263"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.70040"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.006304"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.11.031"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-03-0148"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.03.004"}],"container-title":["Pediatric Blood &amp; 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