{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:19:36Z","timestamp":1788304776619,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Duffy null phenotype is common in people of African ancestry and is associated with lower baseline white blood cell (WBC) and neutrophil counts. We evaluated whether the presence of the Duffy null phenotype had any association with neutropenia in our patients with sickle cell disease on hydroxyurea (HU). We found a statistically significant difference (<jats:italic>p<\/jats:italic> = 0.006) in HU maximum tolerated dose (MTD) in patients with Duffy null phenotype compared with Duffy\u2010positive individuals. Our study suggests that careful dose escalation is warranted in Duffy\u2010null individuals.<\/jats:p>","DOI":"10.1002\/pbc.31693","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T12:39:11Z","timestamp":1743165551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Duffy Null and Its Impact on Hydroxyurea Dosing in Children With Sickle Cell Disease"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3731-3928","authenticated-orcid":false,"given":"Jill S.","family":"Menell","sequence":"first","affiliation":[{"name":"St. Joseph's Children's Hospital  Paterson New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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