{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:25:47Z","timestamp":1783571147283,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic role of systemic inflammation markers in pediatric soft\u2010tissue sarcomas (STS) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>\n                      This multicenter study investigated the prognostic significance of neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), lymphocyte\u2010to\u2010monocyte ratio (LMR), systemic immune\u2010inflammation index (SII), systemic inflammatory response index (SIRI), C\u2010reactive protein (CRP), and lactate dehydrogenase (LDH) in 213 pediatric patients diagnosed with STS in years 2002\u20132023. Patients were categorized into groups: rhabdomyosarcoma (RMS,\n                      <jats:italic>n<\/jats:italic>\n                      = 126), RMS\u2010like (\n                      <jats:italic>n<\/jats:italic>\n                      = 57), and non\u2010RMS (\n                      <jats:italic>n<\/jats:italic>\n                      = 30). Clinicopathological data, including complete blood counts (CBCs), CRP, and LDH levels, were collected and age\u2010adjusted. Optimal cutoffs for predicting outcomes were determined, and the prognostic value of the inflammatory markers was assessed using Kaplan\u2013Meier survival analysis, log\u2010rank tests, and Cox regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences in NLR, PLR, LMR, and CRP levels were observed between RMS, RMS\u2010like, and non\u2010RMS groups. However, LDH levels were significantly elevated in the RMS group compared with the RMS\u2010like group. A consistent trend toward higher NLR, PLR, and CRP values was noted in patients with more advanced disease stages. Multivariate Cox regression analysis across the entire cohort identified CRP (HR 3.39, 95% CI 1.55\u20137.4,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), NLR (HR 2.06, 95% CI 1.07\u20133.99,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), and disease stage (HR = 0.49, 95% CI 0.26\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.035) as independent prognostic factors for survival. Subgroup analyses revealed that the prognostic impact of these markers varied across histopathological subtypes, with limited utility in the RMS\u2010like group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight the prognostic value of systemic inflammatory markers in pediatric STS, emphasizing their potential to refine risk assessment and guide treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31701","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:54:06Z","timestamp":1744372446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Role of Systemic Inflammatory Markers in Pediatric Soft\u2010Tissue Sarcoma: A Multicenter Study of 213 Patients"],"prefix":"10.1002","volume":"72","author":[{"given":"Anna","family":"Gabrych","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata A.","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-1319","authenticated-orcid":false,"given":"Malgorzata","family":"Styczewska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2549-9054","authenticated-orcid":false,"given":"Weronika","family":"Lyzinska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology University Clinical Center in Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"Weclawek\u2010Tompol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and BMT University of Wroclaw Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Dachowska\u2010Kalwak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and BMT University of Wroclaw Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernarda","family":"Kazanowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and BMT University of Wroclaw Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Sawicka\u2010Zukowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Krawczuk\u2010Rybak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Richert\u2010Przygonska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Collegium Medicum, Nicolaus Copernicus University, Antoni Jurasz University Hospital Bydgoszcz 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