{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:50:19Z","timestamp":1783792219210,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","award":["ID 91 172"],"award-info":[{"award-number":["ID 91 172"]}],"id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018820","name":"Farmer of Oelufgaard Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018820","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R192\u2010A11.590"],"award-info":[{"award-number":["R192\u2010A11.590"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic syndrome (MetS), a risk factor for early cardiovascular morbidity and mortality, is seen in up to 34% of survivors of childhood acute lymphoblastic leukemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>We performed a Danish, national cross\u2010sectional study of ALL survivors (aged 1\u201345 years at diagnosis) treated according to the NOPHO ALL2008 protocol, examined at least 1 year after treatment cessation. The study included non\u2010cancer community controls, matched on sex and age. We explored the prevalence and components of the MetS criteria (hyperglycemia, hypertension, increased waist circumference (WC), and dyslipidemia) and glucose homeostasis (insulin and C\u2010peptide).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 366 survivors of ALL (participation rate 84%) and 368 controls. Median age (IQR) at follow\u2010up examination was 14.1 (10.8\u201321.8) years, and follow\u2010up time after the ALL diagnosis was 6.9 (4.7\u20139.1). The prevalence of MetS in survivors was 7.6% and in controls 3.8 % (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.039). The increased MetS prevalence was driven by ALL patients undergoing total body irradiation (TBI), and age and body mass index (BMI) percentile \u226595 at diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.01). The MetS prevalence in non\u2010TBI patients did not differ from controls (\n                      <jats:italic>p =<\/jats:italic>\n                      0.43), but non\u2010TBI patients more often fulfilled the MetS criteria WC and\/or elevated high\u2010density lipoprotein (\n                      <jats:italic>p &lt;<\/jats:italic>\n                      0.03). Survivors had higher serum insulin and C\u2010peptide than controls (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ALL survivors have an increased risk of MetS compared with controls, essentially driven by the patients treated with TBI. The MetS frequency in non\u2010TBI patients is equal to controls, but non\u2010TBI patients more often have one or two components of Mets. ALL survivors seem slightly more insulin\u2010resistant than controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31705","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T23:33:38Z","timestamp":1745969618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of Metabolic Syndrome and Glucose Homeostasis Among Childhood and Young Adult Acute Lymphoblastic Leukemia Survivors: Part of the ALL\u2010STAR Study"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-4814","authenticated-orcid":false,"given":"Mette Tiedemann","family":"Skipper","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital, and Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Birkeb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital, and Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Beck","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital\u2013Herlev  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente Lomholt","family":"Langdahl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital, and Department of Clinical Medicine, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Tuckuviene","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder Skov","family":"Wehner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology H.C. Andersen Children's Hospital Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-4993","authenticated-orcid":false,"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8495-5274","authenticated-orcid":false,"given":"Thomas Leth","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine and Mary Elizabeth's Hospital Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv","family":"Andr\u00e9s\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-3694","authenticated-orcid":false,"given":"Birgitte Klug","family":"Albertsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital, and Department of Clinical Medicine Aarhus University  Aarhus 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