{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:47:48Z","timestamp":1775868468758,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001442"],"award-info":[{"award-number":["UL1TR001442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sociocontextual factors, including social determinants of health (SDOH), affect health outcomes and clinical progression in chronic blood diseases such as hemophilia. Continuous prophylaxis with intravenous clotting factor concentrates or subcutaneous factor VIII mimetic agents reduces bleeding and improves quality of life. However, adherence to prophylaxis is challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the impact of clinical and sociocontextual factors, including SDOH, on adherence to prophylaxis in children and adolescents with hemophilia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, parent and adolescent participants were enrolled from 2018 to 2023. Adherence to prophylaxis was measured by Hemophilia Regimen Treatment Adherence Scale\u2010Prophylaxis as overall adherence as well as \u201ctime,\u201d \u201cdose,\u201d \u201cplan,\u201d \u201cremember,\u201d \u201cskip,\u201d and \u201ccommunicate\u201d subscales. Sociocontextual factors were assessed by self\u2010reported validated surveys. Linear regression analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 41 parent participants, 56% were Hispanic. There was no difference in adherence scores between Hispanic and non\u2010Hispanic parents (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.97). Older age of child (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), prophylaxis via peripheral intravenous route (vs. central line,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004), and use of Spanish language for medical communication (vs. English,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) were associated with lower adherence. Higher trust in provider was associated with higher adherence (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.051).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings may help guide tailored interventions to improve adherence, including targeting older children\/adolescents as they become independent in their care, language\u2010concordant education, and measures to improve social support and enhance trust in healthcare providers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31712","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:08:18Z","timestamp":1745798898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Clinical Characteristics and Sociocontextual Factors on Medication Adherence in Children and Adolescents With Hemophilia"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-2045","authenticated-orcid":false,"given":"Natasha S.","family":"Bala","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-1532","authenticated-orcid":false,"given":"Paula","family":"Aristizabal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology University of California San Diego  La Jolla California USA"},{"name":"Peckham Center for Cancer and Blood Disorders Rady Children's Hospital  San Diego California USA"},{"name":"Division of Population Sciences Disparities and Community Engagement University of California San Diego Moores Cancer Center  La Jolla California USA"},{"name":"Dissemination and Implementation Science Center University of California San Diego Altman Clinical and Translational Research Institute  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euyhyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Altman Clinical and Translational Research Institute  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Altman Clinical and Translational Research Institute  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-8958","authenticated-orcid":false,"given":"Courtney D.","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology University of California San Diego  La Jolla California USA"},{"name":"Peckham Center for Cancer and Blood Disorders Rady Children's Hospital  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12618"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12301"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"152","article-title":"Physical Activity Improved by Adherence to Prophylaxis in an Italian Population of Children, Adolescents and Adults With Severe Hemophilia A: The SHAPE Study","volume":"18","author":"Zanon E.","year":"2020","journal-title":"Blood Transfusion"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.04.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14072"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02813.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12463"},{"issue":"1","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169880","article-title":"Adherence to Prophylaxis in Adolescents and Young Adults With Severe Hemophilia: A Quantitative Study With Patients","volume":"12","author":"Os S. 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