{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:32:41Z","timestamp":1787869961633,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chimeric antigen receptor (CAR) T\u2010cell therapy has emerged as a treatment option for pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia and non\u2010Hodgkin's lymphoma. However, limited information is available regarding the neuropsychological sequelae associated with this treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>This study utilized a multisite, retrospective chart review methodology to describe neuropsychological functioning of pediatric patients prior to and following CAR T\u2010cell infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the pre\u2010infusion cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 26), 39% demonstrated weaknesses (characterized as &gt; 1 SD below the normative mean) on at least one neuropsychological measure, most typically set\u2010shifting, visual motor integration, sustained attention, phonemic fluency, graphomotor processing speed, auditory working memory, and nondominant fine motor functions. In the post\u2010infusion cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 23), 33% demonstrated impairments (characterized as \u2265 1.5 SD below the normative mean) in full\u2010scale intelligence quotient, graphomotor processing speed, visual\u2010motor integration, and fine motor speeded dexterity. Weaknesses (&gt; 1 SD below the normative mean) in sustained attention, narrative verbal memory, academic skills, verbal fluency, and visual memory were also evident in this cohort. In the pre\u2010post\u2010infusion cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 6), 83% demonstrated at least one neuropsychological score that declined across time; however, there was variability in the neuropsychological domains that changed. As a group, academic skills declined over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While conclusions should be tempered given the heterogeneity of the patient population, these findings offer preliminary evidence for specific neuropsychological outcomes in pediatric patients treated with CAR T\u2010cell therapy. Limitations and implications for future practice are discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31716","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:52:22Z","timestamp":1744332742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuropsychological Functioning in Pediatric Patients With Leukemia or Lymphoma Treated With CAR T\u2010Cell Therapy: A Retrospective Chart Review"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9544-9000","authenticated-orcid":false,"given":"Rachel K.","family":"Peterson","sequence":"first","affiliation":[{"name":"Center for Neuropsychological and Psychological Assessment Kennedy Krieger Institute  Baltimore Maryland USA"},{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen T.","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuropsychology Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Sy","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-029X","authenticated-orcid":false,"given":"Lisa A.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Center for Neuropsychological and Psychological Assessment Kennedy Krieger Institute  Baltimore Maryland USA"},{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Janzen","sequence":"additional","affiliation":[{"name":"Department of Psychology &amp; Division of Hematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon N.","family":"Hammer","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah\u2010Lise T.","family":"Schofield","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010018\u20100164\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201099\u2010112572"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2018.07.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102019\u2010123742"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.03.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.09.037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.103126"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1999.1174"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000241"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000733"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly064"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30493\u20100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1188049"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.06.027"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17579"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acac056"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27983"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acq005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acx028"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26446"}],"container-title":["Pediatric Blood &amp; 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