{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:49:07Z","timestamp":1775868547965,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thrombocytopenia is a common challenge in the neonatal intensive care unit, traditionally managed with platelet transfusions. However, transfusions are associated with significant risks, including increased mortality and neurodevelopmental impairment. This case series highlights the use of romiplostim, a thrombopoietin receptor agonist, in three neonates with thrombocytopenia. Each case demonstrated notable improvements in platelet counts without adverse events, reducing dependency on transfusions. These findings underscore romiplostim's potential as a safer alternative for managing neonatal thrombocytopenia. This report advocates for further research to explore romiplostim's efficacy and safety in this vulnerable population, emphasizing its promise in improving neonatal outcomes.<\/jats:p>","DOI":"10.1002\/pbc.31753","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:19:40Z","timestamp":1745972380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility and Safety of Romiplostim as an Alternative to Platelet Transfusion for Neonates"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7548-4064","authenticated-orcid":false,"given":"Rachel N.","family":"Zeno","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Oncology, and BMT Cleveland Clinic Lerner College of Medicine and Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology, and BMT Cleveland Clinic Lerner College of Medicine and Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Lesmana","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology, and BMT Cleveland Clinic Lerner College of Medicine and Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5546\/aap.2021.eng.e202"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.04.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.03.004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009\u20100332"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103476(05)81705\u20106"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.0507"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101086"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807320"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102022\u2010324915"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.52394"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.08.001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(84)80308\u2010x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2019_261"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824\u20107288\u201040\u2010S2\u2010A41"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004863.pub5"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(05)82217\u20106"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.93.6.918"},{"issue":"3","key":"e_1_2_5_19_1","first-page":"173","article-title":"Recombinant human Erythropoietin Therapy for Treatment of Anemia of Prematurity in Very Low Birth Weight Infants: A Randomized, Double\u2010blind, Placebo\u2010controlled Trial","volume":"18","author":"Kumar P.","year":"1998","journal-title":"Journal of Perinatology: Official Journal of the California Perinatal Association"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(97)70089\u20101"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.50"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S47240"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26003"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.3530.3530"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201010\u2010313908"},{"key":"e_1_2_5_26_1","unstructured":"Research C for DE and. 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