{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:52:18Z","timestamp":1784875938917,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whole abdominal radiotherapy (WART) is utilized in children, adolescents, and young adults with intra\u2010abdominal sarcoma, but efficacy and toxicity are uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sarcoma patients diagnosed at \u226439\u00a0years of age between 1998 and 2023 who received WART were identified from a national registry. Patient and tumor characteristics, treatment, response, and survival outcomes were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients with desmoplastic small round cell tumor (DSRCT) (<jats:italic>n<\/jats:italic> = 7), rhabdomyosarcoma (RMS) (<jats:italic>n<\/jats:italic> = 6), Ewing sarcoma, rhabdoid tumor, endometrial stromal tumor (each <jats:italic>n<\/jats:italic> = 1), and sarcoma not\u2010otherwise\u2010specified (NOS) (<jats:italic>n<\/jats:italic> = 4) were included. Among 17 patients who received WART as part of upfront therapy, 16 had abdominal metastatic disease (94.1%) (peritoneal deposits <jats:italic>n<\/jats:italic> = 9, malignant ascites <jats:italic>n<\/jats:italic> = 8 [including two with both peritoneal deposits and malignant ascites] and liver metastases <jats:italic>n<\/jats:italic> = 1), while one was initially localized. Median WART dose was 22.5\u00a0Gy (range: 10.5\u201330); median kidney and liver doses were 14.9\u00a0Gy (range: 7.7\u201320.7) and 21.0\u00a0Gy (range: 13.1\u201327.7), respectively. Three patients developed Grade 3 acute toxicity; diarrhea (<jats:italic>n<\/jats:italic> = 2) or elevated creatinine (<jats:italic>n<\/jats:italic> = 1); two RMS patients developed second malignancies. Two\u2010year overall and progression\u2010free survival estimates were 100% and 80% (95% confidence interval [CI]: 51.6%\u2013100%) in RMS; 62.5% (95% CI: 32%\u2013100%) and 50% (95% CI: 22.5%\u2013100%) in DSRCT. Five\u2010year cumulative incidence of abdominal recurrence was 33.3% (95% CI: 11.4%\u201357.3%) with WART failure in DSRCT (<jats:italic>n<\/jats:italic> = 2) and sarcoma NOS (<jats:italic>n<\/jats:italic> = 1). Three patients received WART following relapse; all recurred; two within the WART field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WART is well tolerated among young sarcoma patients and provides meaningful local disease control when utilized in front\u2010line adjuvant therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31768","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T23:54:06Z","timestamp":1747180446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Whole Abdominal Radiotherapy Is Tolerable and Effective in Children and Young Adults With Intra\u2010Abdominal Sarcoma: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) Study"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-4383","authenticated-orcid":false,"given":"Rebecca J.","family":"Deyell","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/BMT B.C. Children's Hospital and Research Institute, BC Cancer  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit Peretz","family":"Soroka","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Princess Margaret Cancer Centre, University of Toronto  Toronto Ontario Canada"},{"name":"Division of Hematology\/Oncology, Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaney","family":"Sharp","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Princess Margaret Cancer Centre, University of Toronto  Toronto Ontario Canada"},{"name":"Division of Hematology\/Oncology, Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Ruus","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/BMT B.C. Children's Hospital and Research Institute, BC Cancer  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-1677","authenticated-orcid":false,"given":"Jeffrey N.","family":"Bone","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/BMT B.C. Children's Hospital and Research Institute, BC Cancer  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai\u2010Kim","family":"Gervais","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, H\u00f4pital Maisonneuve Rosemont University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Roux","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, H\u00f4pital Maisonneuve\u2010Rosemont University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-8198","authenticated-orcid":false,"given":"Xiaolan","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Tom Baker Cancer Center  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Logie","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Tom Baker Cancer Center  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-6916","authenticated-orcid":false,"given":"Nicolas","family":"Prudhomme","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-2006","authenticated-orcid":false,"given":"Caroline","family":"Holloway","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, BC Cancer, University of British Columbia  Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-5070","authenticated-orcid":false,"given":"Abha A.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Princess Margaret Cancer Centre, University of Toronto  Toronto Ontario Canada"},{"name":"Division of Hematology\/Oncology, Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9762-6901","authenticated-orcid":false,"given":"Derek S.","family":"Tsang","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"issue":"9","key":"e_1_2_8_2_1","article-title":"Updates in Pathology for Retroperitoneal Soft Tissue Sarcoma","volume":"9","author":"Mack T.","year":"2022","journal-title":"Current Oncology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10090642"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02871-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25088"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27805"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1333-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.455"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.02.046"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.06.1985"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.01.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.02.040"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010018\u20106333\u20109"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.10.013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030607"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100586"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26934"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1078039"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:45:24Z","timestamp":1754916324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/pbc.31768"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31768","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"2025-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31768"}}