{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:14:02Z","timestamp":1782454442006,"version":"3.54.5"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100024099","name":"Philips Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019462","name":"Saban Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronically transfused patients with sickle cell disease (SCD) and beta thalassemia major (TM) develop iron overload.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine the impact of iron overload on glucose regulation in SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study of 28 patients with SCD and 38 patients with TM who underwent liver and pancreas <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>* measurements and oral glucose tolerance tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Impaired fasting glucose (2 vs. 9, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.27) and impaired glucose tolerance (1 vs. 11, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019) were less common in patients with SCD compared with patients with TM. No SCD patient had diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron\u2010mediated glucose dysregulation is present but less common in SCD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31780","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:13:43Z","timestamp":1747095223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Significance of Pancreatic Iron in Transfusion\u2010Dependent Sickle Cell Disease"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8346-0284","authenticated-orcid":false,"given":"Akhila","family":"Vadivelan","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology UCLA Mattel Children's Hospital  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eamon","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology USC Keck School of Medicine Children's Hospital of Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cancer and Blood Disease Institute Section of Hematology USC Keck School of Medicine Children's Hospital of Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Denton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cancer and Blood Disease Institute Section of Hematology USC Keck School of Medicine Children's Hospital of Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Veluswamy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cancer and Blood Disease Institute Section of Hematology USC Keck School of Medicine Children's Hospital of Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hofstra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cancer and Blood Disease Institute Section of Hematology USC Keck School of Medicine Children's Hospital of Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Coates","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cancer and Blood Disease Institute Section of Hematology USC Keck School of Medicine Children's Hospital of Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-3439","authenticated-orcid":false,"given":"John C.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology USC Keck School of Medicine Children's Hospital of Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.447"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14575"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13809"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22223"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2016.058"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00939.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-119039"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:44:34Z","timestamp":1754916274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/pbc.31780"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31780","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"assertion":[{"value":"2024-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31780"}}