{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:48:18Z","timestamp":1773398898673,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA098543"],"award-info":[{"award-number":["U10CA098543"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA180899"],"award-info":[{"award-number":["U10CA180899"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["CA285492\u201002"],"award-info":[{"award-number":["CA285492\u201002"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>CHIPS (Childhood Hodgkin International Prognostic Score), a predictive score for event\u2010free\u2010survival (EFS), was originally developed using factors presenting at diagnosis in patients with intermediate\u2010risk Hodgkin lymphoma (HL). Prospective validation of CHIPS in patients was a pre\u2010specified aim of AHOD1331, a trial comparing brentuximab\u2010vedotin, doxorubicin, vincristine, etoposide, prednisone, and cyclophosphamide (Bv\u2010AVEPC) to standard ABVE\u2010PC (and response\u2010adapted radiation) in children with high\u2010risk HL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AHOD1331 was a multicenter randomized phase 3 study. Patients were aged 2\u201321\u00a0years with untreated stages IIB+bulk, IIIB, IV HL. CHIPS was determined by assigning one point each for: Stage IV disease, large mediastinal adenopathy (greater than one\u2010third thoracic diameter), albumin (&lt;3.5\u00a0g\/dL), and fever (<jats:italic>T<\/jats:italic>\u00a0\u2265\u00a038\u00b0C). Associations between CHIPS, baseline patient, and disease characteristics were tested. The validity of CHIPS to predict EFS was evaluated by both overall and within pre\u2010specified subgroups defined by treatment arm, PET2 response, and disease stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The four CHIPS components were analyzable in 576 of the 587 eligible patients. Distribution of CHIPS did not differ by study treatment arm (<jats:italic>p<\/jats:italic> = 0.158). CHIPS was significantly prognostic for EFS in this high\u2010risk cohort (<jats:italic>p<\/jats:italic> = 0.008) and was independently predictive of EFS regardless of treatment arm, PET2 response, or stage. In subset analyses, CHIPS remained independently prognostic among patients with PET2 rapid responding lesions (RRL; <jats:italic>p<\/jats:italic> = 0.021) or Stage IVB disease (<jats:italic>p<\/jats:italic> = 0.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CHIPS were predictive of EFS in patients with high\u2010risk HL treated on AHOD1331. CHIPS may aid in the allocation of patients to risk\u2010based treatment algorithms, and can serve as an effective, inexpensive, and feasible proxy for more biologically based factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31856","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T03:23:54Z","timestamp":1749871434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Childhood Hodgkin International Prognostic Score (CHIPS) in High\u2010Risk Pediatric Hodgkin Lymphoma Patients Treated on Children's Oncology Group AHOD1331"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-0395","authenticated-orcid":false,"given":"Jennifer A.","family":"Belsky","sequence":"first","affiliation":[{"name":"Department of Pediatrics Indiana University\/Riley Hospital for Children  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay A.","family":"Renfro","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Southern California and Children's Oncology Group  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank G.","family":"Keller","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Emory University School of Medicine\/Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-0823","authenticated-orcid":false,"given":"Angela","family":"Punnett","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"McCarten","sequence":"additional","affiliation":[{"name":"Imaging and Radiation Oncology Core\u2010Rhode Island  Lincoln Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve Y.","family":"Cho","sequence":"additional","affiliation":[{"name":"Wisconsin Institute for Medical Research  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Statistics &amp; Data Center  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Roswell Park Comprehensive Cancer Center University at Buffalo Jacobs School of Medicine and Biomedical Sciences  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Emory University School of Medicine\/Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201007\u2010641035"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2023.101445"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206660"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33948"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7042"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.17_suppl.LBA4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.52.5410"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199811193392104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201010\u2010184143"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.41.1819"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.21.1425"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201004\u2010278796"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2006.0024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10978"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000329"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22664"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.9.6808"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj243"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2002.12.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2002.03.051"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.41.0910"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102019\u2010132195"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010164720"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26278"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.02.020"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190903040048"},{"key":"e_1_2_10_28_1","unstructured":"R Team \u201cThe R Project for Statistical Computing \u201dR Foundation https:\/\/www.r\u2010project.org\/)."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.10.50"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405888"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006903\u2010x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.01115"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020959"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201024\u20100942"}],"container-title":["Pediatric Blood &amp; 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