{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T04:10:18Z","timestamp":1756181418435,"version":"3.44.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the safety and efficacy of multimodality treatment with vincristine, actinomycin D, and cyclophosphamide (VAC) therapy, surgery, and radiotherapy according to the US Intergroup Rhabdomyosarcoma Study IV (IRS\u2010IV), and to establish a central review system and standard treatment for intermediate\u2010risk pediatric rhabdomyosarcoma in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>The Japan Rhabdomyosarcoma Study\u2010I (JRS\u2010I) was a single\u2010arm, phase II trial for intermediate\u2010risk rhabdomyosarcoma treatment with open enrollment from June 2004 to March 2009. Patients received 12 cycles of VAC every 3 weeks for 42 weeks, with local therapy beginning after Week 12. The endpoints were progression\u2010free survival (PFS), overall survival (OS), and incidence of hepatic veno\u2010occlusive disease (VOD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one eligible patients were enrolled, and at a median follow\u2010up of 5.2 years, the 3\u2010year PFS and OS for patients were 74.2%\u00a0\u00b1\u00a07.9% (95% confidence interval [CI] 55.0%\u201386.2%) and 90.3%\u00a0\u00b1\u00a05.3% (95% CI 72.9%\u201396.8%), respectively. VOD occurred in 3 (8%) of the 40 evaluable patients, but all recovered, and there were no deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The VAC regimen for intermediate\u2010risk rhabdomyosarcoma with the first central review system in Japan is safe and feasible, and these findings can be positioned as basic data for improving treatment outcomes in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31894","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:39:10Z","timestamp":1751593150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Results of a Phase II Trial for Intermediate\u2010Risk Rhabdomyosarcoma Treatment Protocol JRS\u2010I: A Report From the Japan Rhabdomyosarcoma Study 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