{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:24:25Z","timestamp":1778084665257,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020187","name":"Macy Easom Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Teratoid hepatoblastoma (HB) is a rare histologic subtype of the most common pediatric liver cancer. Understanding of the clinicopathologic features and outcomes of patients with this disease is currently limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multi\u2010institution, retrospective chart review was conducted to compare 20 children with teratoid HB to 129 children with non\u2010teratoid HB treated from 2004 to 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients with teratoid HB, 31% showed teratoid histology in pre\u2010treatment biopsies. All 20 patients received neoadjuvant chemotherapy, with treated tumors showing melanin (14), neuroepithelium with or without glial cells (10), squamous epithelium and whorls (9), mucinous and\/or non\u2010mucinous glandular elements (8), primitive endoderm\/yolk sac\u2010like areas (3), and mature and\/or immature ganglion cells (3). Metastatic and relapsed lesions did not show teratoid histology in this cohort. Teratoid HB was more frequent in males (M:F 1.9:1) and children &lt;5 years old. Patients with teratoid HB were less chemoresponsive and had more metastases at presentation. Rates of prematurity, multifocal disease, vascular invasion, primary surgical management strategy (i.e., resection or transplant), relapse, and survival were comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Teratoid HB occurs in younger patients and is more likely to be chemoresistant. Despite higher rates of metastases at presentation, survival was comparable between the two groups. This is one of the largest series evaluating the clinicopathologic features and outcomes of children with teratoid\u2010HB and is the first to directly compare outcomes between teratoid and non\u2010teratoid subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31903","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:44:57Z","timestamp":1752731097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Teratoid Hepatoblastoma: Clinicopathologic Features and Outcomes"],"prefix":"10.1002","volume":"72","author":[{"given":"Brian T.","family":"Hickner","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery Michael E. DeBakey Department of Surgery Texas Children's Surgical Oncology Program and Liver Tumor Program Dan L. Duncan Cancer Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8716-3125","authenticated-orcid":false,"given":"Andres F.","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Michael E. DeBakey Department of Surgery Texas Children's Surgical Oncology Program and Liver Tumor Program Dan L. Duncan Cancer Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-6858","authenticated-orcid":false,"given":"Soo Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Sarabia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Urbicain","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Michael E. DeBakey Department of Surgery Texas Children's Surgical Oncology Program and Liver Tumor Program Dan L. Duncan Cancer Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev A.","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Michael E. DeBakey Department of Surgery Texas Children's Surgical Oncology Program and Liver Tumor Program Dan L. Duncan Cancer Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6584-420X","authenticated-orcid":false,"given":"Dolores H.","family":"L\u00f3pez\u2010Terrada","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyani R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30505"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.80"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.48013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30598-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70272-9"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"1","article-title":"Hepatoblastoma\u2010The Evolution of Biology, Surgery, and Transplantation","volume":"6","author":"Lim I. I. P.","year":"2018","journal-title":"Children (Basel)"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.6013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24038"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.08.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.07.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12408"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4537"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246135"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.01070.x"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"308","article-title":"A Rare Case of Adult Hepatoblastoma With Neuroendocrine Differentiation Misdiagnosed as Neuroendocrine Tumor","volume":"6","author":"Zhang Q.","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0212-CR"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199009000-00006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931115)72:10<2910::AID-CNCR2820721009>3.0.CO;2-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/jiaps.JIAPS_102_18"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v1i6.281"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442110"},{"issue":"4","key":"e_1_2_10_24_1","first-page":"565","article-title":"Teratoid' Hepatoblastoma: An Intriguing Variant of Mixed Epithelial\u2010Mesenchymal Hepatoblastoma","volume":"9","author":"Sergi C. M.","year":"2022","journal-title":"Children (Basel)"},{"issue":"4","key":"e_1_2_10_25_1","first-page":"311","article-title":"The Effect of Chemotherapy on Hepatoblastoma","volume":"108","author":"Forouhar F. A.","year":"1984","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2001.42.4.431"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-241197"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T03:43:19Z","timestamp":1756179799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/pbc.31903"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31903","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]},"assertion":[{"value":"2024-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31903"}}