{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:20:41Z","timestamp":1785522041313,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is expected that blinatumomab will be increasingly incorporated into the care of children with B\u2010lineage acute lymphoblastic leukemia (B\u2010ALL) based on improved survival for subsets of patients and a favorable safety profile. Most of the 28\u2010day continuous infusion can be administered in outpatient or home settings. Limited studies have described low rates of complications at home when appropriate safety plans are in place. However, home administration shifts the burden of monitoring and care to caregivers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Caregivers of children with B\u2010ALL within 1\u00a0month of completing a first cycle of blinatumomab at home were recruited from three tertiary care centers and participated in virtual, audio\u2010recorded, semi\u2010structured interviews, with translation services available as required. Interviews were transcribed, coded independently in duplicate, and analyzed using thematic analysis. Identified caregiving context\u2010specific barriers and facilitators were coded deductively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participating caregivers (<jats:italic>n<\/jats:italic> = 21) described a time\u2010bound confidence response where initial infusion anxiety was gradually replaced with caregiving self\u2010assurance. Growing confidence co\u2010occurred with improved caregiver wellness and child quality of life, characterized by resuming more usual family activities amid therapy. Barriers and facilitators to successful home\u2010based blinatumomab included caregiver knowledge and skills, access to hospital\u2010based support, and particular aspects of a family's social and material environment, and these underpinned recommendations for future caregivers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Caregivers can confidently manage home\u2010based continuous infusion blinatumomab with anticipatory guidance and support, and with attention paid to context\u2010related modifiers to care. Caregiver insights should be reflected in the principles that become the basis of future pediatric B\u2010cell ALL clinical trials and care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31913","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T06:04:42Z","timestamp":1753164282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Caregiving for Children With Acute Lymphoblastic Leukemia Receiving Home\u2010Based Blinatumomab: Caregiver Experiences and Recommendations"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1755-7203","authenticated-orcid":false,"given":"Sue","family":"Zupanec","sequence":"first","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"},{"name":"Hospital For Sick Children  Toronto Ontario 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