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Caregivers completed questionnaires to assess caregiver adverse childhood experiences (ACEs), recent emotional distress, and resilience, as well as caregiver\/child sociodemographic and clinical factors. A chart review was conducted to assess pediatric healthcare utilization outcomes, and the Area Deprivation Index (ADI) assessed family socioeconomic disadvantage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results indicated that caregivers of youth with SCD and a comorbid condition reported higher levels of recent emotional distress than their counterparts. Additionally, higher no\u2010show rates across all outpatient care were associated with younger caregiver age and higher levels of sociodemographic disadvantage amongst families of youth with SCD. Older youth were found to have more adherence concerns and SCD\u2010related urgent services, and youth with severe SCD demonstrated higher rates of urgent services and SCD\u2010related hospitalizations compared to their counterparts. Finally, higher levels of caregiver ACEs predicted lower rates of attendance in the SCD Clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Child factors, such as comorbidity status, may affect the psychosocial well\u2010being of caregivers of youth with SCD. Additionally, various caregiver and child factors may affect routine and urgent healthcare use, including caregiver\/child age, SCD disease severity, sociodemographic disadvantage, and caregiver ACEs. Better understanding of these relationships may provide opportunities for improved care for youth with SCD and their families.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31939","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:32:59Z","timestamp":1755498779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Caregiver Well\u2010Being and Pediatric Healthcare Utilization in Youth With Sickle Cell Disease: The Role of Caregiver and Child Factors"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6168-0423","authenticated-orcid":false,"given":"Theresa L.","family":"Kapke","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Jane B. 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