{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T04:10:17Z","timestamp":1756181417054,"version":"3.44.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cerebral sinus venous thrombosis (CSVT) varies between pediatric and adult patients in presentation and outcomes. This study compared clinical characteristics, risk factors, treatment patterns, and outcomes in these age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of patients diagnosed with CSVT (2012\u20132023) was conducted. Demographic, clinical, and outcome data were analyzed, including recanalization, recurrent thrombosis, and bleeding events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2012 to 2023, 242 patients were identified (157 adults, 85 children). Children (median age: 2.83\u00a0years) predominantly presented with provoked CSVT (85.9% vs. 63.1% in adults, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), often due to head and neck infections (34.1% vs. 3.8%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Adults (median age: 41.5\u00a0years) had higher rates of hormonal (20.4%) and idiopathic cases (36.9% vs. 14.1%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Headache was the most common symptom in adults (63.1% vs. 30.6% in children, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), while children frequently presented with seizures (31.8% vs. 8.3%, <jats:italic>p<\/jats:italic> &lt; 0.0001). Treatment duration was longer in adults, with two\u2010thirds requiring extended anticoagulation (66.2% vs. 11.76% in children). Pediatric treatment favored low\u2010molecular\u2010weight heparin (75.3%), while adults more commonly received warfarin (45.2%) or direct oral anticoagulants (DOACs) (10.2%). Recanalization rates were higher in children (87% vs. 67.5%, <jats:italic>p<\/jats:italic> = 0.0009), and recurrent thrombosis was more frequent in adults (5.7% vs. 1.17%). Rates of major bleeding were comparable in both groups (4.7% in children vs. 2.55% in adults, <jats:italic>p<\/jats:italic> = 0.457).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CSVT exhibits age\u2010specific differences in risk factors, clinical presentation, treatment patterns, and outcomes. Pediatric cases, typically provoked, require shorter treatment durations and show higher recanalization rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31941","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T05:19:06Z","timestamp":1753852746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Specific Differences in Cerebral Sinus Venous Thrombosis: A Retrospective Cohort Study From a Tertiary Care Center"],"prefix":"10.1002","volume":"72","author":[{"given":"Yarden Peley","family":"Neuman","sequence":"first","affiliation":[{"name":"School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasem","family":"Sawaid","sequence":"additional","affiliation":[{"name":"School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Pediatrics Sheba Medical Center Tel Hashomer  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omri","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Kaplan Medical Center and The Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Department of Medicine and Surgery University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadan","family":"Lalezari","sequence":"additional","affiliation":[{"name":"National Hemophilia Center &amp; Institute of Thrombosis &amp; Hemostasis Sheba Medical Center Tel HaShomer  Ramat Gan Israel"},{"name":"The Amalia Biron Research Institute of Thrombosis and Hemostasis Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-8409","authenticated-orcid":false,"given":"Assaf Arie","family":"Barg","sequence":"additional","affiliation":[{"name":"National Hemophilia Center &amp; Institute of Thrombosis &amp; Hemostasis Sheba Medical Center Tel HaShomer  Ramat Gan Israel"},{"name":"The Amalia Biron Research Institute of Thrombosis and Hemostasis Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat Waldman","family":"Radinsky","sequence":"additional","affiliation":[{"name":"National Hemophilia Center &amp; Institute of Thrombosis &amp; Hemostasis Sheba Medical Center Tel HaShomer  Ramat Gan Israel"},{"name":"The Amalia Biron Research Institute of Thrombosis and Hemostasis Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gili","family":"Kenet","sequence":"additional","affiliation":[{"name":"National Hemophilia Center &amp; Institute of Thrombosis &amp; Hemostasis Sheba Medical Center Tel HaShomer  Ramat Gan Israel"},{"name":"The Amalia Biron Research Institute of Thrombosis and Hemostasis Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aharon","family":"Lubetzky","sequence":"additional","affiliation":[{"name":"National Hemophilia Center &amp; Institute of Thrombosis &amp; Hemostasis Sheba Medical Center Tel HaShomer  Ramat Gan Israel"},{"name":"The Amalia Biron Research Institute of Thrombosis and Hemostasis Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-0336","authenticated-orcid":false,"given":"Sarina","family":"Levy\u2010Mendelovich","sequence":"additional","affiliation":[{"name":"School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"National Hemophilia Center &amp; Institute of Thrombosis &amp; Hemostasis Sheba Medical Center Tel HaShomer  Ramat Gan Israel"},{"name":"The Amalia Biron Research Institute of Thrombosis and Hemostasis Tel Aviv University  Tel Aviv Israel"},{"name":"Talpiot Leadership Program Sheba Medical Center Tel HaShomer  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2106545"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000456"},{"key":"e_1_2_10_4_1","first-page":"755","article-title":"Cerebral Venous Thrombosis","volume":"112","author":"Cohen O.","year":"2021","journal-title":"Minerva Medica"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1019671"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11051280"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100143"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2010.03.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(19)30364-0"},{"key":"e_1_2_10_10_1","first-page":"1182","article-title":"Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors\u2010A Retrospective Unicentric Study","volume":"9","author":"Filip C.","year":"2022","journal-title":"Children (Basel)"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13381"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-024-00320-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03678.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13140"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70131-X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.07.005"},{"key":"e_1_2_10_17_1","first-page":"23","article-title":"Risk Factors of Cerebral Vein and Sinus Thrombosis","volume":"23","author":"Freitas G. 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