{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:12:37Z","timestamp":1778775157148,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R234\u2010A14118"],"award-info":[{"award-number":["R234\u2010A14118"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Endothelial damage may play a key role in several non\u2010infectious toxicities following hematopoietic stem cell transplantation (HSCT). We explored damage to the endothelial glycocalyx in 113 children undergoing HSCT by measuring syndecan\u20101 plasma levels. Syndecan\u20101 levels were elevated in patients with severe sinusoidal obstruction syndrome (SOS) and steroid\u2010refractory\/dependent acute graft\u2010versus\u2010host disease, but remained low in milder cases. In patients with SOS, high syndecan\u20101 levels were associated with prolonged diuretic treatment and thrombocytopenia. These findings provide new insights into the pathophysiology of endothelial\u2010related toxicities after HSCT and may lead to the development of more individualized and targeted therapeutic approaches.<\/jats:p>","DOI":"10.1002\/pbc.31943","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T13:15:45Z","timestamp":1753449345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Syndecan\u20101 is Associated With Sinusoidal Obstruction Syndrome and Severe Acute Graft\u2010Versus\u2010Host Disease After Pediatric Hematopoietic Stem Cell Transplantation"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7501-770X","authenticated-orcid":false,"given":"Denise Elb\u00e6k","family":"Horan","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Institute for Inflammation Research Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-4445","authenticated-orcid":false,"given":"Sarah","family":"Weischendorff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r I.","family":"Johansson","sequence":"additional","affiliation":[{"name":"CAG Center for Endotheliomics Department of Clinical Immunology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Ifversen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus H.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Institute for Inflammation Research Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Institute for Inflammation Research Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-012X","authenticated-orcid":false,"given":"Katrine","family":"Kielsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Institute for Inflammation Research Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Immunology and Microbiology University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.4591.4591"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2991\/chi.d.190317.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.08.024"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2023.101975"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010018\u20102292\u20106"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12831"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0204-7"},{"key":"e_1_2_10_10_1","first-page":"19","article-title":"Profound Endothelial Damage Predicts Impending Organ Failure and Death in Sepsis","volume":"41","author":"Johansen M. 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