{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:25:44Z","timestamp":1777591544439,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011692","name":"Children's Cancer and Leukaemia Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute leukaemias are the commonest cancers in children and young people (CYP). Off\u2010treatment surveillance is assumed to improve relapse detection, but whether this affects subsequent survival and quality of life is unclear. This systematic review searched 13 databases and two trial registries in December 2022. Studies after 1990 investigating post\u2010treatment surveillance in CYP \u226417\u00a0years old with acute leukaemias were included. Extracted outcomes included overall and event\u2010free survivals, surveillance programme performance and cost\u2010effectiveness. Screening, data extraction and quality assessment (using the Quality in Prognostic Studies tool) were conducted in duplicate. Data were narratively synthesised. Of 7899 records screened, 64 studies were included, of which 30 evaluated post\u2010chemotherapy surveillance. 5672 CYP (5181 ALL, 491 AML) were included. 747 CYP experienced 800 relapses. Poor reporting hindered data extraction and quality assessment. Symptom\u2010detected relapses were most common. Surveillance did not impact survival outcomes. Two studies demonstrated the high costs of surveillance programmes. No study reported on the experience or burdens of surveillance. The currently available evidence suggests that there is little support for the role of surveillance in detecting relapse in CYP with acute leukaemia. Prospective, longitudinal, randomised studies focused on key outcomes and high\u2010quality reporting are needed. PROSPERO: CRD42023389281<\/jats:p>","DOI":"10.1002\/pbc.31973","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T03:35:33Z","timestamp":1757302533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Do Surveillance Tests for Relapse Improve Survival After Chemotherapy for Paediatric Acute Leukaemia? A Systematic Review"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-2100","authenticated-orcid":false,"given":"Connor","family":"Evans","sequence":"first","affiliation":[{"name":"Centre for Reviews and Dissemination University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hollie","family":"Melton","sequence":"additional","affiliation":[{"name":"Centre for Reviews and Dissemination University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Reviews and Dissemination University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca E.","family":"Ling","sequence":"additional","affiliation":[{"name":"MRC Weatherall Institute of Molecular Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Moppett","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Bristol Royal Hospital for Children  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-9673","authenticated-orcid":false,"given":"Bob","family":"Phillips","sequence":"additional","affiliation":[{"name":"Centre for Reviews and Dissemination University of York  York UK"},{"name":"Department of Paediatric Haematology and Oncology Leeds Children's Hospital  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Royal Hospital for Children  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Fulbright","sequence":"additional","affiliation":[{"name":"Centre for Reviews and Dissemination University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-8638","authenticated-orcid":false,"given":"Jessica E.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Centre for Reviews and Dissemination University of York  York UK"},{"name":"Department of Paediatric Haematology and Oncology Leeds Children's Hospital  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Children's Cancer and Leukaemia Group (CCLG) \u201cChildhood Cancer in Numbers \u201d accessed June 5 2024 https:\/\/www.cclg.org.uk\/childhood\u2010cancer\u2010in\u2010numbers."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.5.1487"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2012.12.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17162"},{"key":"e_1_2_10_6_1","unstructured":"B.Gibson K.Wheatley P.Kearns et\u00a0al. \u201cMyeChild 01: International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia\u2014Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination With Induction Chemotherapy: Protocol v1.0a \u201dUniversity of Birmingham 2015 https:\/\/www.birmingham.ac.uk\/Documents\/college\u2010mds\/trials\/crctu\/myechild\u201001\/Protocol\/MyeChild\u201001\u2010Protocol\u2010v1.0a\u201004Aug2015.pdf."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcped.2023.100010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001619\u20109"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-023-04635-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3110"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-018-2901-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27509"},{"key":"e_1_2_10_13_1","unstructured":"J.Morgan C.Evans H.Melton R.Ling H.Fulbright andY.Liu \u201cDo Routine Surveillance Investigations Improve Survival After Paediatric Acute Leukaemia? 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