{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:05:59Z","timestamp":1758758759562,"version":"3.44.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Acute myeloid leukemia (AML) is most often incurable in low\u2010resource settings. To address this challenge, the International Society of Paediatric Oncology (SIOP) developed an intensity\u2010adapted AML practice guideline in 2019. Here, we present the protocol of an observational\u2010implementation study evaluating the SIOP guideline in Malawi. The purpose of this manuscript is to present a novel application of hybrid effectiveness\u2010implementation designs adaptable to a wide spectrum of pediatric hematology\u2010oncology diseases and contexts. Here, we propose hybrid designs as an option for teams in low\u2010resource settings to evaluate current practice and generate much\u2010needed evidence to inform adoption decisions regarding adapted treatment strategies.<\/jats:p>","DOI":"10.1002\/pbc.32005","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:40:47Z","timestamp":1756467647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Implementation Success of an Intensity\u2010Adapted Guideline for Pediatric Acute Myeloid Leukemia in Malawi: An Observational\u2010Implementation Study Protocol"],"prefix":"10.1002","volume":"72","author":[{"given":"Noel","family":"Mwango","sequence":"first","affiliation":[{"name":"Baylor College of Medicine Children's Foundation  Lilongwe Malawi"},{"name":"Texas Children's Hospital Global HOPE  Houston Texas USA"},{"name":"Kamuzu Central Hospital National Cancer Centre  Lilongwe Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Chirwa","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children's Foundation  Lilongwe Malawi"},{"name":"Texas Children's Hospital Global HOPE  Houston Texas USA"},{"name":"Kamuzu Central Hospital National Cancer Centre  Lilongwe Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Phalula","sequence":"additional","affiliation":[{"name":"University of North Carolina Chapel Hill Project Malawi  Lilongwe Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizine","family":"Mzikamanda","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children's Foundation  Lilongwe Malawi"},{"name":"Texas Children's Hospital Global HOPE  Houston Texas USA"},{"name":"Kamuzu Central Hospital National Cancer Centre  Lilongwe Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nmazuo","family":"Ozuah","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Global HOPE  Houston Texas USA"},{"name":"Kamuzu Central Hospital National Cancer Centre  Lilongwe Malawi"},{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Bulsara","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Hilsenbeck","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Hosseinipour","sequence":"additional","affiliation":[{"name":"University of North Carolina Chapel Hill Project Malawi  Lilongwe Malawi"},{"name":"University of North Carolina Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gertjan J. L.","family":"Kaspers","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht Netherlands"},{"name":"Emma Children's Hospital Amsterdam UMC  Amsterdam Netherlands"},{"name":"Vrije Universiteit  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Rau","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Montealegre","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Global HOPE  Houston Texas USA"},{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-4668","authenticated-orcid":false,"given":"Casey L.","family":"McAtee","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Global HOPE  Houston Texas USA"},{"name":"Kamuzu Central Hospital National Cancer Centre  Lilongwe Malawi"},{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"95","article-title":"Abandonment and Outcome of Childhood Acute Myeloid Leukemia in a Tertiary Level Hospital","volume":"27","author":"Begum M.","year":"2018","journal-title":"Mymensingh Medical Journal"},{"key":"e_1_2_8_3_1","unstructured":"N.Howlader A.Noone M.Krapcho et\u00a0al. \u201cSEER Cancer Statistics Review 1975\u20132017. 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