{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:37:22Z","timestamp":1790872642181,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Phase 1 trials may expose pediatric oncology patients to potential adverse effects beyond drug\u2010related toxicity, including delays in advance care planning and suboptimal quality of end\u2010of\u2010life (EoL) care. Pediatric palliative care (PPC) can provide symptom management support and assist with EoL planning and care for patients and families enrolling in Phase 1 trials; however, little is known about children with cancer who enroll in Phase 1 studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective medical record review of pediatric oncology patients enrolled on a Phase 1 clinical trial over a 9\u2010year period was completed at an academic cancer hospital. Data collected included sociodemographic, clinical, and EoL\u2010related variables. Descriptive analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total 539 patient charts met the inclusion criteria for review; 53% (<jats:italic>n<\/jats:italic> = 285) were male, 76% (<jats:italic>n<\/jats:italic> = 411) were Caucasian, and 82% (<jats:italic>n<\/jats:italic> = 442) were deceased. Central nervous system (CNS) tumors were the most common diagnosis (44%, <jats:italic>n<\/jats:italic> = 237), followed by leukemias (33%, <jats:italic>n<\/jats:italic> = 179), solid tumors (20%, <jats:italic>n<\/jats:italic> = 108), and lymphomas (3%, <jats:italic>n<\/jats:italic> = 15). All patients enrolled in at least one Phase 1 study, with 15% (<jats:italic>n<\/jats:italic> = 83) enrolling in two or more. The median length of time on study was 62\u00a0days, with time on study decreasing for subsequent Phase 1 trial participation. Two\u2010thirds of patients (68%, <jats:italic>n<\/jats:italic> = 368) had PPC consultation; however, only 21% (<jats:italic>n<\/jats:italic> = 76) had PPC consulted prior to Phase 1 trial enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although most patients enrolled in Phase 1 studies have PPC involvement, referrals are typically made far beyond trial enrollment. Earlier and systematic PPC integration in this high\u2010risk patient population may offer the potential benefit of maximal EoL support, care, and planning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.32010","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T13:33:01Z","timestamp":1757165581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Describing Pediatric Oncology Patients Enrolled in Phase 1 Clinical Trials"],"prefix":"10.1002","volume":"72","author":[{"given":"Andrea","family":"Cuviello","sequence":"first","affiliation":[{"name":"Division of Palliative Medicine Phoenix Children's  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Trejo","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine New York University, Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennesse USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena","family":"Levine","sequence":"additional","affiliation":[{"name":"Division of Quality of Life and Palliative Care St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-3666","authenticated-orcid":false,"given":"Holly","family":"Spraker\u2010Perlman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology and Palliative Medicine University of Utah\/Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa042220"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0615"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0046"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29230"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.9.1900"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-73639-6_11"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26748"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.0277"},{"issue":"5","key":"e_1_2_10_11_1","first-page":"S829","article-title":"Palliative Care as a Standard of Care in Pediatric Oncology","volume":"62","author":"Weaver M. 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