{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:05:48Z","timestamp":1779541548240,"version":"3.53.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>All the patients treated in a prospective trial (December 1999\u2013April 2013) were included. Data were collected from a prospective database and supplemented by a retrospective review of the patients\u2019 files. Local control alone rate, progression\u2010free survival (PFS), and overall survival (OS) were assessed. Multivariate analyses were conducted to adjust for classical prognosis factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010two patients, median age 13.6 years, were included. All received induction chemotherapy. Surgery was completed (R0) in 88%. Overall, 66% had good histological response (GR). Radiotherapy (RT) was performed on the primary tumor in 28%, on the hemithorax in 13%, or on both in 32%. With a median follow\u2010up of 12 years, 28 patients (34%) relapsed. Five\u2010year local control rate was 95% (95%CI [89%\u201395%]), 5\u2010year PFS was 73% (95%CI [62%\u201381%]), and 5\u2010year OS was 79% (95%CI [69%\u201387%]). In multivariate analysis, pleural effusion was significantly associated with poor PFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.049). In the case of R0 and GR (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a041), no significant difference in PFS\/OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.16\/\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.36) was reported according to adjuvant local RT. Overall, 38% of scoliosis and 7.3% of secondary cancer were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A multidisciplinary approach in high\u2010risk patients can provide good local control in rib ES. In patients who have undergone R0 surgery and are GR, omitting adjuvant RT of the surgical bed may be discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32012","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T13:35:02Z","timestamp":1757165702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series"],"prefix":"10.1002","volume":"73","author":[{"given":"Audrey","family":"Claren","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Centre De Haute Energie  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2393-5821","authenticated-orcid":false,"given":"Alexandre","family":"Beige","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre L\u00e9on B\u00e9rard  Lyon 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Radiation Oncology Institut De Canc\u00e9rologie de L'ouest  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"V\u00e9rit\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Centre Hospitalier Universitaire De Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Marec\u2010B\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Institut D'h\u00e9matologie Et D'oncologie P\u00e9diatrique  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jolnerovski","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Institut De Canc\u00e9rologie de Lorraine\u2014Alexis Vautrin  Nancy 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