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In some of these cases, chemotherapy is required after birth, given tumor progression that threatens the functional prognosis (dumbbell neuroblastoma), or even survival (Stage MS). However, the optimal doses of chemotherapy in premature newborns are not known. We present a retrospective cohort of six patients treated in French pediatric oncology centers in order to analyze treatment modalities, and report on their tolerance (five Grade 4 hematological toxicity, three septicemias) as well as the outcome of these newborns (two deaths, four remissions).<\/jats:p>","DOI":"10.1002\/pbc.32027","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:09:23Z","timestamp":1758776963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcome of Premature Infants Treated With Chemotherapy for Neuroblastoma in France"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6684-9447","authenticated-orcid":false,"given":"Dana","family":"Al Khalifa","sequence":"first","affiliation":[{"name":"Pediatric Hematology and Oncology Department Children's University Hospital of Nancy  Vandoeuvre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Chastagner","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department Children's University Hospital of Nancy  Vandoeuvre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-5879","authenticated-orcid":false,"given":"Gudrun","family":"Schleiermacher","sequence":"additional","affiliation":[{"name":"SIREDO Integrated Pediatric Oncology Center Institut Curie  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Clocheville Hospital University Hospital of Tours  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573396311666150714105727"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513810701696890"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15968"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100142(19970715)80:2<304::aid\u2010cncr19>3.0.co;2\u2010y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010490273037"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.5.8166007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601154"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19920915)70:6<1625::aid\u2010cncr2820700631>3.0.co;2\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.6.2007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.477"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.472"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.11.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2004.01.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010008\u20100787\u20106"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010016\u20102975\u20100.E"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100142(19960715)78:2<311::aid\u2010cncr19>3.0.co;2\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.4.1047"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27825"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5148"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101065340"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010016\u20100263\u20106"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142141"}],"container-title":["Pediatric Blood &amp; 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