{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:57:29Z","timestamp":1765976249895,"version":"3.48.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Extracorporeal photopheresis (ECP) is an attractive treatment for graft\u2010versus\u2010host disease (GVHD) following allogeneic hematopoietic stem cell transplantation due to the lack of systemic immunosuppression. Modifications of ECP without leukapheresis are being actively studied in clinical practice around the world. A low\u2010volume method of extracorporeal photochemotherapy\u2014micro\u2010ECP\u2014has been developed at the Rogachev Federal Scientific and Clinical Centre of Pediatric Hematology, Oncology and Immunology. We present the results of using micro\u2010ECP to treat acute and chronic GVHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We analyzed the treatment outcomes of 9 cases of acute GVHD and 15 cases of chronic GVHD using micro\u2010ECP for the period from April 2021 to March 2024. The cellular product was obtained by collecting 20\u201330\u00a0mL of whole blood followed by photochemical treatment. The processed autologous cell product was administered to the patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall response rate in patients diagnosed with acute GVHD was 44%, while the organ\u2010specific response rate was 56% for skin and 40% for gastrointestinal. The steroid\u2010sparing effect for acute GVHD was 89%. In the treatment of chronic GVHD, the overall response rate was 73.3%. The organ\u2010specific response rate was 71% for skin, 67% for gastrointestinal, 67% for lung, 100% for eyes, and 100% for liver chronic GVHD. The steroid\u2010sparing effect for chronic GVHD was 63%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the treatment of acute and chronic GVHD, micro\u2010ECP has demonstrated promising efficacy. Although the method remains experimental, it is already apparent that micro\u2010ECP constitutes an attractive alternative to standard ECP when leukapheresis is not a viable option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32039","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:49:38Z","timestamp":1757908178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microphotopheresis for the Treatment of Graft\u2010Versus\u2010Host Disease in Pediatric Patients"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-1041","authenticated-orcid":false,"given":"Irina","family":"Kumukova","sequence":"first","affiliation":[{"name":"Rogachev Federal Scientific and Clinical Centre of Pediatric Hematology Oncology and Immunology  Moscow Russia"},{"name":"Moscow Multidisciplinary Clinical Center \u201cKommunarka\u201d of the Moscow Health Care Department  Moscow Russia"},{"name":"Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation Barrikadnaya str  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-5382","authenticated-orcid":false,"given":"Elena","family":"Kurnikova","sequence":"additional","affiliation":[{"name":"Rogachev Federal Scientific and Clinical Centre of Pediatric Hematology Oncology and Immunology  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-3310","authenticated-orcid":false,"given":"Julia","family":"Garloeva","sequence":"additional","affiliation":[{"name":"Rogachev Federal Scientific and Clinical Centre of Pediatric Hematology Oncology and Immunology  Moscow 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Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-5630","authenticated-orcid":false,"given":"Larisa","family":"Shelikhova","sequence":"additional","affiliation":[{"name":"Rogachev Federal Scientific and Clinical Centre of Pediatric Hematology Oncology and Immunology  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-053X","authenticated-orcid":false,"given":"Julia","family":"Skvortsova","sequence":"additional","affiliation":[{"name":"Rogachev Federal Scientific and Clinical Centre of Pediatric Hematology Oncology and Immunology  Moscow 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Available at: https:\/\/www.health.state.mn.us\/communities\/ep\/surge\/burn\/tbsa.html."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:48:40Z","timestamp":1765975720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.32039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,14]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pbc.32039"],"URL":"https:\/\/doi.org\/10.1002\/pbc.32039","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2025,9,14]]},"assertion":[{"value":"2025-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e32039"}}