{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:57:36Z","timestamp":1765976256750,"version":"3.48.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Moyamoya syndrome (MMS) is a chronic vasculopathy characterized by progressive stenosis of intracerebral arteries, leading to an increased risk of stroke. Children with Down syndrome (DS) are at an increased risk of co\u2010occurring medical conditions, including MMS and leukemia. We report four patients with the triad of DS, MMS, and acute lymphoblastic leukemia (ALL). Two patients had a diagnosis of MMS prior to developing ALL, whereas two were diagnosed with MMS during ALL therapy. This series highlights the need to remain cognizant of MMS in patients with DS and ALL, particularly in those with acute neurologic changes.<\/jats:p>","DOI":"10.1002\/pbc.32045","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T03:39:32Z","timestamp":1757302772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Moyamoya Syndrome in Patients With Down Syndrome and Acute Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-8113","authenticated-orcid":false,"given":"Robert","family":"Lisac","sequence":"first","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-8664","authenticated-orcid":false,"given":"Ryan J.","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. John","family":"Bergsagel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank G.","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Philbrook","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Child Neurology, Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wrubel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-0974","authenticated-orcid":false,"given":"Gary","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil S.","family":"Raikar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"volume-title":"StatPearls","year":"2023","author":"Rupareliya C.","key":"e_1_2_7_2_1"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"175","article-title":"Moyamoya Disease in Asia","volume":"7","author":"Han C.","year":"2012","journal-title":"Neurology Asia"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073817718730"},{"volume-title":"StatPearls","year":"2023","author":"Akhtar F.","key":"e_1_2_7_5_1"},{"volume-title":"Data and Statistics on Birth Defects","year":"2024","author":"Centers for Disease Control and Prevention","key":"e_1_2_7_6_1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010057010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.17294\/2330\u20100698.1824"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804622"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000003277"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2024.1.JNS221977"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163628"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200030501"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010012\u20101732\u20106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11\u20102308"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000072872"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20837"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u2010964903"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104558"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31827b9beb"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00389"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2014.959923"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221144089"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213484"}],"container-title":["Pediatric Blood &amp; 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