{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:57:58Z","timestamp":1765976278392,"version":"3.48.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA095861"],"award-info":[{"award-number":["U10CA095861"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA180886\u201006S1"],"award-info":[{"award-number":["U10CA180886\u201006S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA98543"],"award-info":[{"award-number":["U10CA98543"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA98413"],"award-info":[{"award-number":["U10CA98413"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["T32CA261787"],"award-info":[{"award-number":["T32CA261787"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of pediatric B\u2010acute lymphoblastic leukemia (B\u2010ALL) impacts both patients and their caregivers. An understanding of family functioning during therapy can inform family\u2010centered care. We aimed to prospectively identify negative and positive changes in family life as perceived by caregivers throughout ALL therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Caregivers of children aged \u22654\u00a0years with average\u2010risk B\u2010ALL enrolled on the Children's Oncology Group trial AALL0932 who consented to an ancillary study were asked: \u201cHow has family life changed since your child's diagnosis of leukemia for the better or for the worse?\u201d Written free responses were collected at approximately 2, 8, 17, 26 (end of therapy for females), and 38 (end of therapy for males) months post\u2010diagnosis. Inductive content analysis was used to create codes, subcategories, and categories. Descriptive statistics were used to characterize the sample and frequencies of reported codes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 994 responses were collected from caregivers of 468 children across all timepoints. Twenty\u2010seven individual codes were identified, categorized by negative changes (reported by 89% of caregivers) and positive changes (reported by 58% of caregivers). Subcategories of negative changes, including changes in daily routines, work and finance, patient health and care needs, effects on other family members, and emotional changes, were identified across all timepoints, but were most prevalent early in therapy. Importantly, positive changes were also identified, including family support, community support, and changes in outlook.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies negative and positive family changes perceived by caregivers of children undergoing B\u2010ALL therapy that can inform future interventions to better support families.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32057","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T06:33:51Z","timestamp":1758350031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caregivers\u2019 Perspectives on Changes in Family Life During B\u2010ALL Therapy: A Qualitative Study From the Children's Oncology Group"],"prefix":"10.1002","volume":"72","author":[{"given":"Alexandra","family":"Dreyzin","sequence":"first","affiliation":[{"name":"Pediatric Oncology Branch and Center for Cellular Engineering National Institutes of Health Clinical Center  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-7520","authenticated-orcid":false,"given":"Megan","family":"Ware","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Health Promotion, and Recreation University of North Texas  Denton Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Stumbras","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's National Hospital  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kairalla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Colleges of Medicine and Public Health &amp; Health Professions University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Hibbitts","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Colleges of Medicine and Public Health &amp; Health Professions University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenna","family":"Mossman","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Georgetown University  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-2623","authenticated-orcid":false,"given":"Lyn","family":"Balsamo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Raetz","sequence":"additional","affiliation":[{"name":"Perlmutter Cancer Center and Department of Pediatrics NYU Langone Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-3091","authenticated-orcid":false,"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The Hospital for Sick Children  Toronto Ontario 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