{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:58:45Z","timestamp":1765976325760,"version":"3.48.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Approximately 20% of infants with Down syndrome\u2010associated transient abnormal myelopoiesis (TAM) die at an early age, mainly because of liver failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify post\u2010diagnosis changes in blood test indices that could predict TAM\u2010related deaths as early as the postnatal period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Results<\/jats:title>\n                    <jats:p>\n                      This was a single\u2010center retrospective study. Of the 505 children with Down syndrome admitted to our hospital from 1992 to 2024, we studied 12 infants with TAM\u2010related death and 39 survivors. In the death and survival groups, the median gestational ages were 34.9 and 37.1\u00a0weeks, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.146). At birth, the white blood cell (WBC) counts were 99.2 and 41.7 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027), and the serum direct bilirubin (D\u2010Bil) concentrations were 20 and 17\u00a0\u00b5mol\/L (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.45), respectively. After the first week of age, the WBC counts, blast percentages, platelet counts, and serum alanine aminotransferase and aspartate aminotransferase concentrations were similar between the groups. At 1\u00a0week of age, the serum D\u2010Bil concentrations were 32 and 21\u00a0\u00b5mol\/L (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007), respectively. At 2\u00a0weeks, they were 94 and 27\u00a0\u00b5mol\/L (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), respectively. The area under the receiver operating characteristic curve for the ability of serum D\u2010Bil at 2\u00a0weeks to predict death was 0.94, with a threshold of \u226551\u00a0\u00b5mol\/L (approximately 3.0\u00a0mg\/dL) yielding a sensitivity of 1.00 and a specificity of 0.78.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A serum D\u2010Bil concentration of \u226551\u00a0\u00b5mol\/L at 2\u00a0weeks of age may serve as a useful predictor of TAM\u2010related death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32064","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T08:21:06Z","timestamp":1758097266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Blood Test Indices of Infants With Down Syndrome\u2010Associated Transient Abnormal Myelopoiesis"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-5521","authenticated-orcid":false,"given":"Hideyuki","family":"Hawaka","sequence":"first","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Shimokaze","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Yokosuka","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Kanagawa Children's Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuaki","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Kanagawa Children's Medical Center  Yokohama 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