{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:57:34Z","timestamp":1765976254575,"version":"3.48.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemorrhagic cystitis (HC) is a frequent and potentially severe complication following hematopoietic stem cell transplantation (HSCT) in children. It significantly affects the quality of life and prolongs hospitalization. Despite its frequency, no standardized management guidelines exist. This study aimed to describe the characteristics, risk factors, and treatments of HC in a pediatric HSCT population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective single\u2010center study including all pediatric patients who underwent allogeneic HSCT between January 2007 and December 2022. HC was defined and graded according to the European Conference on Infections in Leukaemia (ECIL) guidelines. We analyzed risk factors, BK virus (BKV) viruria, treatments, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HC occurred in 24 patients (14.7%), with a median onset at 27.5\u00a0days post\u2010HSCT. Acute graft\u2010versus\u2010host disease (aGVHD) was significantly associated with HC occurrence (45.8% vs. 19.4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), particularly in its severe forms (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007). BKV was detected in 66.7% of HC cases. Viral load in urine was not significantly associated with HC severity or duration. All patients received supportive care; cidofovir was used in 79.2%, with increasing frequency in higher grade HC. Severe cases required multimodal management, including intravesical installations, hyperbaric oxygen therapy (HBO; 37.5%), and arterial embolization (all Grade 4 cases). No deaths were directly attributed to HC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HC remains a significant and morbid complication after pediatric HSCT. Our findings highlight the need for early identification of high\u2010risk patients and access to timely, multidisciplinary interventions. Multicenter prospective studies are essential to standardize care and improve outcomes in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32071","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:50:26Z","timestamp":1758628226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation in Children: A Single Pediatric Center Experience"],"prefix":"10.1002","volume":"72","author":[{"given":"Pauline","family":"Mazilier","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Bone Marrow Transplantation Universit\u00e9 Libre de Bruxelles (ULB) H\u00f4pital Universitaire de Bruxelles (HUB) H\u00f4pital Universitaire des Enfants Reine Fabiola  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Dedeken","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Bone Marrow Transplantation Universit\u00e9 Libre de Bruxelles (ULB) H\u00f4pital Universitaire de Bruxelles (HUB) H\u00f4pital Universitaire des Enfants Reine Fabiola  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonore","family":"Powis","sequence":"additional","affiliation":[{"name":"Hyperbaric Oxygen Center H\u00f4pital Militaire Reine Astrid  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Bone Marrow Transplantation Universit\u00e9 Libre de Bruxelles (ULB) H\u00f4pital Universitaire de Bruxelles (HUB) H\u00f4pital Universitaire des Enfants Reine Fabiola  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Luyckx","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urogical Surgery Universit\u00e9 Libre de Bruxelles (ULB) H\u00f4pital Universitaire de Bruxelles (HUB) H\u00f4pital Universitaire des Enfants Reine Fabiola  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Kornreich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Bone Marrow Transplantation Universit\u00e9 Libre de Bruxelles (ULB) H\u00f4pital Universitaire de Bruxelles (HUB) H\u00f4pital Universitaire des Enfants Reine Fabiola  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safiatou","family":"Diallo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Bone Marrow Transplantation Universit\u00e9 Libre de Bruxelles (ULB) H\u00f4pital Universitaire de Bruxelles (HUB) H\u00f4pital Universitaire des Enfants Reine Fabiola  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Salaroli","sequence":"additional","affiliation":[{"name":"Institut Jules Bordet  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Devalck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Bone Marrow Transplantation Universit\u00e9 Libre de Bruxelles (ULB) H\u00f4pital Universitaire de Bruxelles (HUB) H\u00f4pital Universitaire des Enfants Reine Fabiola  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-021-03120-y"},{"issue":"2","key":"e_1_2_9_4_1","first-page":"141","article-title":"BK Virus Infections and Hemorrhagic Cystitis in Allogeneic Hematopoietic Stem Cell Transplant Recipients","volume":"46","author":"S\u00f6kmen H.","year":"2023","journal-title":"New Microbiologica"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.05.013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx324"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01505.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2018.03.018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.05.002"},{"issue":"5","key":"e_1_2_9_10_1","first-page":"217","article-title":"Treatment Protocols for BK Virus Associated Hemorrhagic Cystitis After Hematopoietic Stem Cell Transplantation","volume":"10","author":"Najafabadi M. M.","year":"2020","journal-title":"American Journal of Blood Research"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BS9.0000000000000110"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2078538"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.12.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-024-04815-x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu043"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.01.014"},{"issue":"3","key":"e_1_2_9_17_1","first-page":"iii36","article-title":"ECIL\u20107 Guidelines for Prevention, Diagnosis and Treatment of BK Virus\u2010Associated Hemorrhagic Cystitis in HSCT Recipients","volume":"76","author":"Cesaro S.","year":"2021","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.0655"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57030278"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:48:51Z","timestamp":1765975731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.32071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pbc.32071"],"URL":"https:\/\/doi.org\/10.1002\/pbc.32071","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"assertion":[{"value":"2025-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e32071"}}