{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:57:30Z","timestamp":1765976250705,"version":"3.48.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA55727"],"award-info":[{"award-number":["CA55727"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare psychosocial health and chronic health conditions (CHCs) in bereaved and non\u2010bereaved adult siblings impacted by childhood cancer and to identify predictors of emotional distress and health\u2010related quality of life among bereaved siblings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 4558 adult siblings (733 bereaved; 3825 non\u2010bereaved) of 5\u2010year survivors of childhood cancer completed measures of emotional distress (Brief Symptom Inventory [BSI]\u201018) and health\u2010related quality of life (Medical Outcomes Survey Short Form [SF]\u201036) and reported their social attainment milestones (i.e., educational attainment, employment, and marital status). CHCs\u2019 burden was classified as none\/low versus medium\/high\/very severe. Cancer\u2010associated complications prior to the patient's death, sibling age at bereavement, and social attainment variables were examined as predictors of emotional distress and health\u2010related quality of life among bereaved siblings using multivariable modified Poisson regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bereaved siblings in this sample reported excellent psychosocial health long term (e.g., depressive symptoms 6.5%, somatization 4.4%, anxiety 3.5%). Bereaved siblings had an elevated risk of depression (relative risk [RR] 1.53; 1.10\u20132.13,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), reduced social quality of life (RR 1.35; 1.00\u20131.82,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05), diminished educational attainment, and greater CHC burden than non\u2010bereaved siblings. No differences were observed for other subscales or social attainment outcomes. Among bereaved siblings, risk factors for depression included male sex (RR 0.42; 0.19\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05), never being married (RR 3.02; 1.45\u20136.28,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05), and greater CHC burden (RR 2.42; 1.18\u20134.99,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05). Risk factors for poor social functioning included unemployment (RR 2.24; 1.12\u20134.45,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05) and never being married (RR 2.16; 1.22\u20133.82,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bereaved siblings report excellent psychosocial health long\u2010term and demonstrate only a marginally elevated risk of experiencing symptoms of depression and poor social quality of life compared to non\u2010bereaved siblings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32076","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T06:54:28Z","timestamp":1759128868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial Health and Chronic Health Conditions Among Bereaved Siblings: A Report From the Childhood Cancer Survivor Study (CCSS)"],"prefix":"10.1002","volume":"72","author":[{"given":"Prachi","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California at Irvine  Irvine California USA"},{"name":"Division of Hematology\/Oncology Children's Hospital of Orange County  Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivya","family":"George","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deokumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Chow","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Alderfer","sequence":"additional","affiliation":[{"name":"Center For Healthcare Delivery Science Nemours Children's Health System  Wilmington Delaware USA"},{"name":"Sidney Kimmel Medical College at Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin A.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Psychological Brain Science Boston University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Lown","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences and Osher Center for Integrative Medicine University of California at San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Oeffinger","sequence":"additional","affiliation":[{"name":"Duke University Health System  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lonnie K.","family":"Zeltzer","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at University of California at Los Angeles (UCLA) and UCLA Jonsson Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-4207","authenticated-orcid":false,"given":"Gregory T.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-7001","authenticated-orcid":false,"given":"Kevin R.","family":"Krull","sequence":"additional","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-6160","authenticated-orcid":false,"given":"Tara M.","family":"Brinkman","sequence":"additional","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-3473","authenticated-orcid":false,"given":"David","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California at Irvine  Irvine California USA"},{"name":"Division of Hematology\/Oncology Children's Hospital of Orange County  Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cLeading Causes of Death Charts \u201dCenters for Disease Control and Prevention National Center for Injury Prevention and Control 2021 accessed October 28 2021 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Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:48:05Z","timestamp":1765975685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.32076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pbc.32076"],"URL":"https:\/\/doi.org\/10.1002\/pbc.32076","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2025,9,28]]},"assertion":[{"value":"2025-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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