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RIF is caused by excessive proliferation of myofibroblasts, which produce collagen and extracellular matrix components, coupled with a reduction of remodeling enzymes. Targeting this pathway with pravastatin to prevent and ameliorate RIF has been shown to improve outcomes in patients with head and neck cancer. We share our single\u2010center experience using pravastatin to treat RIF involving the joints in children with sarcomas who developed RIF, as well as in a population administered prophylactically.<\/jats:p>","DOI":"10.1002\/pbc.32084","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:44:01Z","timestamp":1759211041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pravastatin for Radiation\u2010Induced Fibrosis of the Extremity: A Single\u2010Center Experience"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-6457","authenticated-orcid":false,"given":"Rachel","family":"Offenbacher","sequence":"first","affiliation":[{"name":"Department of Pediatrics Albert Einstein College of Medicine and Division of Pediatric Hematology Oncology and Cellular Therapy Children's Hospital at Montefiore  Bronx New York 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