{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:29:34Z","timestamp":1768469374983,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Iron deficiency (ID) and iron deficiency anemia (IDA) are prevalent among children and adolescents, affecting growth and development. Although oral iron is the first\u2010line treatment, intravenous (IV) iron is required in cases of poor tolerance or inadequate response. While some IV formulations are used in pediatric clinical practice, no published data on the safety and efficacy of iron isomaltoside (IIM) in the pediatric population exist, while data on low\u2010molecular\u2010weight dextran (LMWD) remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Our retrospective cohort study at Vilnius University Hospital Santaros Klinikos (2021\u20132023) included pediatric patients (&lt;18 years) with ID\/IDA receiving IIM or LMWD. Hematological response assessment was based on reticulocyte hemoglobin equivalent (Ret\u2010He) and reticulocyte percentage at 3\u20137 days (early response), and red blood cell count, hemoglobin (HGB), mean corpuscular volume, serum ferritin, and transferrin saturation at 4\u20136 weeks (late response).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010two patients (IIM: 50, LMWD: 22; 135 infusions), 68% female, with a median age of 13.5 years, were included in the study. Mean HGB increase was 32.4\u00a0g\/L (IIM) versus 33.1\u00a0g\/L (LMWD) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.9). Median ferritin increase was 71.4\u00a0\u00b5g\/L (IIM) versus 117.8\u00a0\u00b5g\/L (LMWD) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.3). Ret\u2010He improved significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Mild AEs occurred in 5.6%, with similar AE rates in both groups (IIM: 6.0%, LMWD: 4.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that IIM and LMWD are effective and safe IV iron therapies for pediatric ID\/IDA. Given the lack of data on the safety and efficacy of IIM in the pediatric population, our findings provide valuable preliminary evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32093","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:33:04Z","timestamp":1759296784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pediatric Intravenous Iron Therapy: Evaluating the Safety and Efficacy of Iron Isomaltoside and Low\u2010Molecular\u2010Weight Dextran"],"prefix":"10.1002","volume":"72","author":[{"given":"Ernesta","family":"Drag\u016bn\u0117","sequence":"first","affiliation":[{"name":"Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u0117","family":"Mork\u016bnait\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaudas Benediktas","family":"Trakymas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramun\u0117","family":"Vai\u0161nor\u0117","sequence":"additional","affiliation":[{"name":"Institute of Data Science and Digital Technologies Faculty of Mathematics and Informatics Vilnius University  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-7116","authenticated-orcid":false,"given":"Sonata","family":"\u0160aulyt\u0117 Trakymien\u0117","sequence":"additional","affiliation":[{"name":"Clinic of Children's Diseases Institute of Clinical Medicine Faculty of Medicine Vilnius University Vilnius University Hospital Santaros Klinikos  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2020.041"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13004"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization.Anaemia. (2023) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/anaemia."},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization.Anaemia Action Alliance. (2025) https:\/\/www.who.int\/teams\/nutrition\u2010and\u2010food\u2010safety\/anaemia\u2010action\u2010alliance."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401038"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30925\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26995"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29024"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2014.04.007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010022\u201004582\u2010w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24201"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22981"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.111492"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i13.2138"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/hemato5010005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.15264\/cpho.2020.27.2.101"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"Kinetik und Regulation Der Erythrocytenproduktion. Experimentelle Untersuchungen an der normalen und An\u00e4mischen Ratte [Kinetics and Regulation of Erythrocyte Production. Experimental Studies on Normal and Anemic Rats]","volume":"31","author":"Ganzoni A. M.","year":"1970","journal-title":"Experimentelle Medizin, Pathologie Und Klinik"},{"issue":"16","key":"e_1_2_10_20_1","first-page":"691","article-title":"Neue Aspekte Des Eisenmangels [New Aspects of Iron Deficiency]","volume":"100","author":"Ganzoni A. M.","year":"1970","journal-title":"Schweizerische Medizinische Wochenschrift"},{"key":"e_1_2_10_21_1","volume-title":"Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Vitamin and Mineral Nutrition Information System","author":"World Health Organization","year":"2011"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2450\/2014.0094\u201014"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.10.007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22930"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24676"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26124"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24633"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25564"},{"key":"e_1_2_10_29_1","unstructured":"Pharmacosmos A\/S. (2025).Multi\u2011center trial of ferric derisomaltose in children 0 to under 18 years of age with iron deficiency anemia (ClinicalTrials.gov Identifier NCT05179226) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05179226."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22450"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010021\u201001770\u20102"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:49:51Z","timestamp":1765975791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.32093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pbc.32093"],"URL":"https:\/\/doi.org\/10.1002\/pbc.32093","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2025-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e32093"}}