{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:42:40Z","timestamp":1768005760905,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As survival after Wilms tumor has markedly improved, focus on potential long\u2010term consequences is necessary. We investigated the metabolic profile among Danish survivors of Wilms tumor &gt;20\u00a0years from cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>As of January 15, 2015, we established a cohort of 20\u2010plus\u2010year survivors of Wilms tumor identified through the national cancer registries. Siblings contributed as controls. Participation included clinical examination with anthropometric measurements, blood samples, blood pressure measurements, and a comprehensive health questionnaire. Using logistic regression, we identified risk factors for diabetes mellitus (DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a response rate of 64%, we included 99 survivors of Wilms tumor with a median of 37\u00a0years since diagnosis (median age of 41, range: 24\u201370), and 38 sibling controls (median age of 41, range: 24\u201366). An increased prevalence of DM was found in the survivors as compared with their siblings (15% vs. 0%). A logistic regression analysis adjusted for age at follow\u2010up showed that left\u2010sided versus right\u2010sided abdominal radiation therapy was a risk factor for the development of DM (odds ratio [OR] 7.9, 95% confidence interval [CI]: 1.4\u201344). A larger fraction of the survivors was in active treatment for hypertension compared to siblings (42% vs. 37%), but with no significant difference in body mass index, hip, or waist circumferences. Furthermore, Wilms tumor survivors were more likely to be in active treatment with lipid\u2010lowering agents (8% vs. 3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Left\u2010sided abdominal radiation is a major risk factor for DM in long\u2010term survivors of Wilms tumor. Patients may benefit from surveillance with increased focus on metabolic risk profile to decrease the risk of DM and cardiovascular events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32097","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T05:10:09Z","timestamp":1760332209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diabetes Mellitus and Metabolic Profile in Long\u2010Term Survivors of Wilms Tumor: A Nationwide Cohort Study With Sibling Controls"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-5432","authenticated-orcid":false,"given":"Stine","family":"H\u00f8gsholt","sequence":"first","affiliation":[{"name":"Pediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirstine","family":"Stochholm","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"},{"name":"Department of Endocrinology Aarhus University Hospital  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Haubjerg","family":"Asdahl","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Rechnitzer","sequence":"additional","affiliation":[{"name":"Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3976-9231","authenticated-orcid":false,"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[{"name":"Pediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus 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