{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:58:21Z","timestamp":1787752701292,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Individuals with neutropenia or defective neutrophil disorders exhibit significantly increased susceptibility to oral infections and dental complications compared to the general population. Despite the elevated risk profile associated with these conditions, comprehensive and standardized dental care guidelines for affected individuals remain limited. Optimal management requires a multidisciplinary approach that incorporates pre\u2010procedural risk stratification, individualized treatment planning, and appropriate post\u2010procedural care strategies. There is a pressing need for well\u2010controlled clinical studies to evaluate the efficacy of prophylactic antibiotic regimens and granulocyte colony\u2010stimulating factor in mitigating infection risks in this vulnerable population. However, the rarity and heterogeneity of neutrophil disorders pose substantial challenges to the development of evidence\u2010based protocols. Risk assessment must be individualized, tailored to individual patient profiles, considering factors such as the degree of neutropenia, prior history of infections, and the nature of planned dental procedures. Here, we review and summarize guidelines for dental management in patients with congenital neutrophil disorders and propose the need for targeted, evidence\u2010based clinical studies to ensure safe and effective care.<\/jats:p>","DOI":"10.1002\/pbc.32145","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:41:30Z","timestamp":1762494090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral and Dental Management in Children With Congenital Neutropenia"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4774-1128","authenticated-orcid":false,"given":"Dany A.","family":"Curi","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics Saint George Hospital University Medical Center Saint George University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie C.","family":"Kabbani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Faculty of Dental Medicine Saint Joseph University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth J.","family":"Corey","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Cancer Biology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_17_2_1","first-page":"3","volume-title":"Methods in Molecular Biology","author":"Malech H. 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