{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:09:55Z","timestamp":1790244595400,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Uveal melanoma is the most common malignant primary intraocular tumor in adults, associated with high mortality. Pediatric uveal melanoma generally has a more favorable course. However, when metastasis occurs, therapeutic options are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Clinical presentation, treatment, and outcome of children with uveal melanoma diagnosed in Germany and Austria between 2013 and 2024 were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Since 2013, 12 children were diagnosed with uveal melanoma in Germany and Austria\u2014nine in the choroid, three in the ciliary body, and iris. Treatment comprised enucleation (five patients), external beam radiation with protons (two patients), ocular brachytherapy (four patients), and endoresection (one patient). Two patients developed metastasis. A 17\u2010year\u2010old male with liver metastasis died 30\u00a0months after diagnosis. A 3\u2010year\u2010old male with metastatic choroidal melanoma presented with metastasis 6\u00a0months after enucleation. Chemotherapy followed by nivolumab and ipilimumab led to a complete response. However, immunotherapy caused insulin\u2010dependent diabetes mellitus. Genetic testing revealed a pathogenic constitutional\n                      <jats:italic>TP53<\/jats:italic>\n                      variant, confirming Li\u2013Fraumeni syndrome (LFS). At 24\u00a0months after diagnosis of metastatic disease, he remains in complete response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This report underscores the rarity and diverse presentation of pediatric choroidal melanoma. Diagnosis of LFS in one patient highlights the importance of genetic testing for tumor predisposition and personalized approaches in managing rare pediatric tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.32147","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:21:47Z","timestamp":1762320107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Melanoma of the Choroid and Ciliary Body in Children: Remission of Metastatic Melanoma of the Choroid After Treatment With Chemotherapy and Immune Checkpoint Inhibition"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1498-8064","authenticated-orcid":false,"given":"Pia","family":"T\u00fcller","sequence":"first","affiliation":[{"name":"Department of Pediatrics III University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Jabbarli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Schramm","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center Heidelberg (KiTZ)  Heidelberg Germany"},{"name":"German Cancer Consortium (DKTK)  Heidelberg Germany"},{"name":"National Center for Tumor Diseases (NCT) Network  Heidelberg Germany"},{"name":"Pediatric Glioma Research Group German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Barwinski","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK)  Heidelberg Germany"},{"name":"Institute of Human Genetics, University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sch\u00f6nberger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines B.","family":"Brecht","sequence":"additional","affiliation":[{"name":"General Pediatrics, Hematology\/Oncology University Children's Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-1601","authenticated-orcid":false,"given":"Dominik T.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Clinic of Pediatrics, Klinikum Dortmund University Witten\/Herdecke  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Fischhuber","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research University of Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Junker","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Ting","sequence":"additional","affiliation":[{"name":"Institute of Pathology Nordhessen  Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Kiewert","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetology, Department of Pediatrics II University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"G\u00f6ricke","sequence":"additional","affiliation":[{"name":"Institute For Diagnostic and Interventional Radiology and Neuroradiology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Bechrakis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Biewald","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8138-0441","authenticated-orcid":false,"given":"Petra","family":"Ketteler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III University Hospital Essen  Essen Germany"},{"name":"Institute of Human Genetics, University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.154367"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.12.1639"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz176"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.12.024"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.5802\/crbiol.63"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16142510"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.296962.117"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103485"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.013"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.418"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02133-6"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1509660"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02229"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00605"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00550"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2022.2116845"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.54"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11071031"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00266-1"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000462975"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.06.009"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0094"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-022-00335-y"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.23.00015"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000200"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000584"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102599"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31010002"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2018-000591"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-019-0467-z"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1215"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.02.006"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04322-5"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-019-01108-x"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1188277"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26040-0"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(93)90142-T"},{"issue":"1","key":"e_1_2_13_39_1","first-page":"75","article-title":"Melanoma in Patients With Li\u2013Fraumeni Syndrome (Review)","volume":"23","author":"Sandru F.","year":"2022","journal-title":"E"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad248"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.32147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:38:02Z","timestamp":1790242682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.32147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/pbc.32147"],"URL":"https:\/\/doi.org\/10.1002\/pbc.32147","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.174713238.89012295\/v1","asserted-by":"object"}]},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e32147"}}