{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:01:48Z","timestamp":1790172108329,"version":"4.1.0"},"reference-count":124,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pneumocystis jirovecii<\/jats:italic>\n                    pneumonia (PJP) remains a modern\u2010day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk\u2010stratified approaches to PJP prophylaxis for pediatric patients with ST. It traces the evolution of prophylaxis strategies over the past six decades, with examination of trends in PJP incidence, fatality, risk factors (including those posed by novel therapeutics), prophylaxis efficacy and safety, international prophylaxis guidelines, and guideline implementation into clinical practice. Although compliant use of prophylaxis effectively prevents PJP, our understanding of specific risk factors and prophylaxis\u2010related toxicity has predominantly been established for pediatric patients with hematological rather than ST. This complicates our assessment of the risks and benefits of PJP prophylaxis for those with ST, resulting in variations in prophylaxis guidance and practices, and is further compounded by increased use of novel immunomodulating agents. These knowledge gaps make it difficult to reliably inform a risk\u2010stratified approach to PJP prophylaxis in pediatric patients with extracranial ST. Further longitudinal research and implementation strategies are required to support the development of effective, standardized PJP prophylaxis practices.\n                  <\/jats:p>","DOI":"10.1002\/pbc.32172","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:35:52Z","timestamp":1767677752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Evolution of\n                    <i>Pneumocystis jirovecii<\/i>\n                    Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8285-1715","authenticated-orcid":false,"given":"Kriti","family":"Kumar","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7379-3439","authenticated-orcid":false,"given":"Denise M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kellington","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse","family":"Zelunka","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Kerrigan","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-0359","authenticated-orcid":false,"given":"Furqan","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-0871","authenticated-orcid":false,"given":"Paul C.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-5181","authenticated-orcid":false,"given":"Meredith S.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-1104","authenticated-orcid":false,"given":"Sarah","family":"Cohen\u2010Gogo","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V39.6.759.759"},{"issue":"6","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/cncr.2820360612","article-title":"Intensity of Immunosuppressive Therapy and the Incidence of Pneumocystis carinii Pneumonitis","volume":"36","author":"Hughes W. T.","year":"1975","journal-title":"Cancer"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80113-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712292972602"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.02130190011004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706253162604"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.10.021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480060078034"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.4836.4836"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003044"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2019.05.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2016.59.6.252"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-319997"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.9912058"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12599"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0149-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000002073"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa436"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad639"},{"key":"e_1_2_8_21_1","first-page":"71","article-title":"Impact of Prophylaxis Choice on Risk of Pneumocystis Pneumonia in Children With Cancer: A Case\u2010control Study","volume":"140","author":"Geerlinks A. V.","year":"2020","journal-title":"European Journal of Cancer 1990"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361231159481"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/515658"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","DOI":"10.1177\/2325958218759199","article-title":"The Impact of Absolute CD4 Count and Percentage Discordance on Pneumocystis jirovecii Pneumonia Prophylaxis in HIV\u2010Infected Patients","volume":"17","author":"Anyimadu H.","year":"2018","journal-title":"International Association of Providers of AIDS Care"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2015.1086366"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0549-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.08.002"},{"issue":"3","key":"e_1_2_8_28_1","first-page":"1375","article-title":"Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide","volume":"85","author":"Stupp R.","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0722"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac072"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2012.762780"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2021.06.010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5863.385"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.07.658"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00060-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1903.121151"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000771"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-016-0450-9"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-769208"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2022.03.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1709866"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062326"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.09.015"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcped.2024.100160"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17175-8"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd6169"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae133"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007474"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.238634"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002732"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007474"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00346-7"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-793760"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.254045"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1885"},{"key":"e_1_2_8_56_1","unstructured":"\u201cProphylaxis\u2014Pneumocystis jirovecii (carinii) Pneumonia in Cancer Patients \u201d eviQ May 19 2023 https:\/\/www.eviq.org.au\/clinical\u2010resources\/side\u2010effect\u2010and\u2010toxicity\u2010management\/prophylaxis\u2010and\u2010treatment\/220\u2010pneumocystis\u2010jirovecii\u2010pneumonia\u2010pjp\u2010prophyl."},{"key":"e_1_2_8_57_1","unstructured":"L.Baden S.Swaminathan N.Almyroudis et\u00a0al. \u201cPrevention and Treatment of Cancer\u2010Related Infections Version 3.2024 \u201d NCCN published online September 23 2024 https:\/\/www.nccn.org\/login?ReturnURL=https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/infections.pdf."},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.07.018"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361211036773"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094496"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24426"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2424"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.3705.3705"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.02.009"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2522"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11277"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-014-0150-1"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt019"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2013.07.003"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2016.1242009"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065166"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1040218"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.15761\/GOD.1000193"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.12.006"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13422"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.14744\/ejmo.2020.89845"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.4103\/JIPO.JIPO_23_19"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01649-6"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001757"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.07.083"},{"issue":"1","key":"e_1_2_8_81_1","first-page":"11","article-title":"A Case of Pneumocystis Jirovecci in a Patient With Non\u2010Small Cell Lung Cancer Treated With Immunotherapy","volume":"106","author":"Sanka P.","year":"2023","journal-title":"Rhode Island Medical Journal (2013)"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1129730"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-4-57"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.11106\/ijt.2019.12.2.127"},{"issue":"3","key":"e_1_2_8_85_1","first-page":"55","article-title":"Risk of Infectious Complications in Hemato\u2010Oncological Patients Treated With Kinase Inhibitors","volume":"10","author":"Reinwald M.","year":"2016","journal-title":"Biomark Insights"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix687"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000804"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26453"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950180406"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-25.2.111"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22562"},{"key":"e_1_2_8_92_1","unstructured":"Committee on Infectious Diseases American Academy of Pediatrics \u201cRed Book: 2024\u20132027 Report of the Committee on Infectious Diseases (33rd Edition) \u201dAmerican Academy of Pediatrics accessed June 10 2025 https:\/\/publications.aap.org\/redbook\/book\/755\/Red\u2010Book\u20102024\u20102027\u2010Report\u2010of\u2010the\u2010Committee\u2010on."},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.4065\/82.9.1052"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1360"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21202"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220979046"},{"issue":"4","key":"e_1_2_8_97_1","first-page":"283","article-title":"Incidence of Pneumocystis jirovecii and Adverse Events Associated with Pneumocystis Prophylaxis in Children Receiving Glucocorticoids","volume":"7","author":"Basiaga M. L.","year":"2017","journal-title":"Journal of the Pediatric Infectious Diseases Society"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00792"},{"key":"e_1_2_8_99_1","first-page":"53","article-title":"Methotrexate and Trimethoprim\u2010Sulfamethoxazole","volume":"60","author":"Cudmore J.","year":"2014","journal-title":"Canadian Family Physician"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426\u2010198100320\u201000001"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12060"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.040"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83351-7"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2024.107151"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00022-3.x"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000606"},{"key":"e_1_2_8_107_1","unstructured":"J.Foster \u201cIndividualized High Dose Methotrexate for the Treatment of Malignancies in Children and Adolescents With a Significant Risk for Methotrexate Toxicities \u201dNIH published online2015 https:\/\/cdn.clinicaltrials.gov\/large\u2010docs\/97\/NCT02076997\/Prot_SAP_000.pdf."},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw157"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000044"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00173-18"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21287"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000946"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.04.011"},{"key":"e_1_2_8_114_1","unstructured":"J.SkeenandR.Sandilya \u201cPneumocystis jirovecii(carinii) Prophylaxis and Pneumonia (PCP) \u201d Starship Hospital published online May 19 2016 https:\/\/starship.org.nz\/guidelines\/pneumocystis\u2010jirovecii\u2010carinii\u2010prophylaxis\u2010and\u2010pneumonia\u2010pcp\/."},{"key":"e_1_2_8_115_1","unstructured":"B.Philips G.Mbah T.Saad et\u00a0al. \u201cClinical Practice Recommendations (CPR) forPneumocystic jiroveciiPneumonia \u201dARIA Program Global Partners published online August2023."},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307515"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31532"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43058-021-00200-2"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1197\/jamia.M1444"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000835"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12961-022-00815-4"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361211036773"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1315"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700978"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20164"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.32172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.32172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:14:33Z","timestamp":1790169273000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.32172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":124,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/pbc.32172"],"URL":"https:\/\/doi.org\/10.1002\/pbc.32172","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e32172"}}