{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:07:03Z","timestamp":1780718823901,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,9,12]],"date-time":"2007-09-12T00:00:00Z","timestamp":1189555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"973 program","doi-asserted-by":"crossref","award":["2006CB504706"],"award-info":[{"award-number":["2006CB504706"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30472134"],"award-info":[{"award-number":["30472134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30672600"],"award-info":[{"award-number":["30672600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Great Research Project of Chinese Academy of Sciences","award":["KGCX2-SW-213-06"],"award-info":[{"award-number":["KGCX2-SW-213-06"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The stability of diester\u2010diterpenoid alkaloids (DDA) from plants of the genus <jats:italic>Aconitum L.<\/jats:italic> has been studied in different solvents and pH buffers. The HPLC\/ESIMS method for analysing the concentration of DDA was established and DDA's decomposition products were elucidated by HPLC\/ESI\u2010MS\/MS<jats:sup><jats:italic>n<\/jats:italic><\/jats:sup>. In different solvents, e.g. dichloromethane, ether, methanol and distilled water, the decomposition pathways of DDA are quite different and their difference in stabilities depends on the difference of their structures, in which substituents at the N atom and substituents at C\u20103 are different. The pyrolytic products of DDA, such as deacetoxy aconitine\u2010type alkaloids, have been observed in the above solvents, whereas 8\u2010methoxy\u201014\u2013benzoyl aconitine\u2010type alkaloids have been obtained only in methanol. Furthermore, the experimental results demonstrate that the stability of DDA depends on pH values of the buffer. Aconine as hydrolysate has been only found in pH 10.0 buffer, and the other hydrolysates and the pyrolyzates of DDA, such as benzoylaconine and deacetoxy aconitine, have been observed in all pH aqueous solutions. The decomposition pathways of DDA in buffers are related to the substituent on the C\u20103 position. The decomposition pathway of aconitine is similar to that of mesaconitine, but different from that of hypaconitine. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pca.1027","type":"journal-article","created":{"date-parts":[[2007,9,12]],"date-time":"2007-09-12T08:46:31Z","timestamp":1189586791000},"page":"141-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Studies on the stability of diester\u2010diterpenoid alkaloids from the genus <i>Aconitum L.<\/i> by high performance liquid chromatography combined with electrospray ionisation tandem mass spectrometry (HPLC\/ESI\/MS<sup>n<\/sup>)"],"prefix":"10.1002","volume":"19","author":[{"given":"Hao","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010feng","family":"Pi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010rui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01498-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(81)90001-5"},{"key":"e_1_2_1_4_1","first-page":"36","article-title":"Physiological action and officinal foreground of diester\u2010diterpenoid alkaloids","volume":"15","author":"Chen DH","year":"1984","journal-title":"Chin Herl Med"},{"key":"e_1_2_1_5_1","first-page":"455","volume-title":"The Ability of Mass Spectrometry in Natural and Organic Chemistry.","author":"Cong PZ","year":"1987"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50064a009"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00942-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957798"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957609"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(98)00235-7"},{"key":"e_1_2_1_11_1","first-page":"367","article-title":"Study of effect between toxicity and decocted time","volume":"4","author":"Jin AP","year":"1997","journal-title":"Shi Zhen J. 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