{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:07:23Z","timestamp":1778767643038,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T00:00:00Z","timestamp":1200355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kutajarista is a well known polyherbal preparation of which the main ingredient is the stem bark of <jats:italic>Holarrhena antidysenterica<\/jats:italic>. This Ayurvedic medicine is prescribed to treat amoebic dysentery and other disorders such as fever, indigestion and malabsorption syndrome. Herbal medicines are very important since, in common with conventional medicines, they contain biologically active substances that may produce non\u2010trivial side effects when taken in excessive amounts. Very low doses, on the other hand, may have no therapeutic value. In this paper we report the chemical standardisation of Kutajarista by HPLC analysis based upon the presence of the biomarker conessine in the formulation. The standardisation method is simple and reliable, and the precision of method has been tested for repeatability (<jats:italic>n<\/jats:italic> = 3) and reproducibility (<jats:italic>n<\/jats:italic> = 9). The response of a refractive index detector was linear in the concentration range of 0.1\u20131.0 mg\/mL. Recovery studies were performed to check the method for accuracy. The recovery was found to be in range of 99\u2013105%. The developed HPLC method can be used to quantify conessine for quality control of marketed Kutajarista samples. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pca.1052","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T13:47:14Z","timestamp":1200404834000},"page":"323-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chromatographic Analysis of Kutajarista\u2014an Ayurvedic Polyherbal Formulation"],"prefix":"10.1002","volume":"19","author":[{"given":"Shivali","family":"Garg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Bhutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,16]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"10","volume-title":"Ayurvedic Formulary of India","year":"2003"},{"key":"e_1_2_1_3_1","first-page":"387","volume-title":"Proceedings of National Symposium of Applied Biotechnology of Medicinal","author":"Bhutani KK","year":"1984"},{"key":"e_1_2_1_4_1","first-page":"21","article-title":"Finger printing of Ayurvedic drugs","volume":"43","author":"Bhutani KK","year":"2000","journal-title":"Eastern Pharm"},{"key":"e_1_2_1_5_1","first-page":"212","article-title":"Profile of Kurchi in India","volume":"21","author":"Bhutani KK","year":"1984","journal-title":"Indian Drugs"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(88)84121-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(90)80057-N"},{"key":"e_1_2_1_8_1","first-page":"20","volume-title":"Pharmacoepical Standards for Ayurvedic Formulations","author":"Central Council for Research in Ayurvedic and Siddha","year":"1987"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00119-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.07.008"},{"key":"e_1_2_1_11_1","first-page":"1","volume-title":"ICH Harmonised tripartite guideline\u2010Q2R1","year":"2005"},{"key":"e_1_2_1_12_1","first-page":"149","article-title":"Conessine as larval growth inhibitor, sterilant, and antifeedant from Holarrhena antidysenterica Wall","volume":"10","author":"Thappa RK","year":"1989","journal-title":"Insect Sci Appl"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpca.1052","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.1052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:54:44Z","timestamp":1761047684000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.1052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,16]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/pca.1052"],"URL":"https:\/\/doi.org\/10.1002\/pca.1052","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,16]]},"assertion":[{"value":"2006-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}