{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:26:50Z","timestamp":1788888410501,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2013,9]]},"abstract":"ABSTRACT<\/jats:title>Introduction<\/jats:title>The leaves of Corylus avellana<\/jats:italic> L. (common hazel, Betulaceae), a plant with a wide distribution in Europe, have been used in folk medicine for various diseases, but phytochemical exploration of C. avellana<\/jats:italic> is still incomplete. To the best of our knowledge there is no previous report concerning diarylheptanoids in C. avellana<\/jats:italic>, although these compounds show a frequent occurrence among Betulaceae plants.<\/jats:p><\/jats:sec>Objective<\/jats:title>To improve existing online chromatographic methods for the investigation of the phenolic compounds in C. avellana<\/jats:italic> leaves and bark, focusing on diarylheptanoid\u2010type molecules.<\/jats:p><\/jats:sec>Methods<\/jats:title>Dried and powdered leaves and bark of C. avellana<\/jats:italic> were extracted with increasing polarity solvents (n<\/jats:italic>\u2010hexane, chloroform, ethyl acetate and methanol) in Soxhlet extractor apparatus. For the characterisation of the phenolic compounds in the ethyl acetate and methanolic extracts, UV spectral data, obtained by LC with a diode\u2010array detector (DAD), accurate molecular mass and formula, acquired by LC and electrospray ionisation (ESI) with time\u2010of\u2010flight (TOF) MS and fragmentation pattern, given by LC\u2013ESI\/MS\/MS analyses were used. Quantitation of the compounds was performed by LC\u2013MS\/MS.<\/jats:p><\/jats:sec>Results<\/jats:title>In the methanolic and ethyl acetate extracts of C. avellana<\/jats:italic> bark four flavonoid glycosides and a caffeoyl hexoside derivative were detected and characterised, while in C. avellana<\/jats:italic> leaves, seven diarylheptanoid\u2010type molecules were tentatively identified in addition to six flavonoid components. As far as we know this is the first study where the presence of diarylheptanoids in C. avellana<\/jats:italic> is reported.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The improved HPLC\/DAD\u2013ESI\/MS method was successfully utilised for the characterisation and quantitation of the phenolic compounds in C. avellana<\/jats:italic> bark and leaves extracts. Copyright \u00a9 2013 John Wiley & Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pca.2452","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T11:53:20Z","timestamp":1373370800000},"page":"493-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Characterisation of Diarylheptanoid\u2010 and Flavonoid\u2010type Phenolics in Corylus avellana<\/i> L. Leaves and Bark by HPLC\/DAD\u2013ESI\/MS<\/scp>"],"prefix":"10.1002","volume":"24","author":[{"given":"Eszter","family":"Riethm\u00fcller","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Semmelweis University H\u20101085 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Alberti","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Semmelweis University H\u20101085 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerg\u0151","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Semmelweis University H\u20101092 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"B\u00e9ni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Semmelweis University H\u20101092 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ortolano","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Palermo I\u201090133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"K\u00e9ry","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Semmelweis University H\u20101085 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.995"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410410001704778"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2010.07.026"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-010-1502-4"},{"key":"e_1_2_5_6_1","first-page":"124","volume-title":"Pharmacogosie phytochimie, plantes m\u00e9dicinales","author":"Bruneton J","year":"1993"},{"key":"e_1_2_5_7_1","first-page":"406","article-title":"Standardization of hazel leaf","volume":"57","author":"Fraisse D","year":"1999","journal-title":"Ann Pharma Francaises"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.06.011"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.01.103"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.810"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-864093"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(199708)11:12<1357::AID-RCM983>3.0.CO;2-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240941"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2007.05.018"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-1978(95)00106-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf062472o"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpca.2452","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpca.2452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.2452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:29:29Z","timestamp":1761046169000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.2452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,9]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/pca.2452"],"URL":"https:\/\/doi.org\/10.1002\/pca.2452","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,9]]},"assertion":[{"value":"2012-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}