{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:45:23Z","timestamp":1761162323017,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Triterpenes are one of the largest secondary metabolites groups spread in the plant kingdom with various skeletons. These metabolites have showed various bioactivities including anti\u2010inflammatory activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The study aims to explore the mass spectrometry fragmentation of donellanic acids A\u2010C (DA A\u2013C), three compounds identified from\n                      <jats:italic>Donella ubanguiensis<\/jats:italic>\n                      ; in addition, the fragmentation behaviour of these metabolites will serve as a fingerprint to search and characterise triterpenes congeners in fruits, bark and wood crude extracts of\n                      <jats:italic>D. ubanguiensis<\/jats:italic>\n                      . This work was prompted by the anti\u2010inflammatory activity on leukocyte migration, exudate concentrations and myeloperoxidase activity obtained for DA A\u2013B.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>The bioactivity was performed on mouse model of pleurisy induced by carrageenan and the parameters were analysed by veterinarian automated cell counter and colorimetric assays. While the tandem mass analyses of DA A\u2013C were carried out by a direct infusion ESI\u2010QTOF\u2010MS\/MS, the extracts were studied by UPLC\u2010ESI\u2010QTOF\u2010MS and UPLC\u2010ESI\u2010QTOF\u2010MS\/MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DA A displayed interesting anti\u2010inflammatory activity by inhibiting leukocyte migration, exudate concentrations and myeloperoxidase activity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) while DA B was weakly active (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). Moreover, the diagnostic of the MS\n                      <jats:sup>2<\/jats:sup>\n                      behaviour of DA A\u2013C in conjunction with the chromatograms and the obtained MS\n                      <jats:sup>2<\/jats:sup>\n                      data of the crude extract led to the characterisation of three cyclopropane triterpenes (T1\u2013T3) and six saponins (T4\u2013T9) from the fruits, the bark, and the wood extracts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Donella<\/jats:italic>\n                      species deserve more investigation since metabolites related to the anti\u2010inflammatory compound (DA A) could be identified. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.2640","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T11:38:03Z","timestamp":1481801883000},"page":"27-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["ESI\u2010MS\n                    <sup>2<\/sup>\n                    and Anti\u2010inflammatory Studies of Cyclopropanic Triterpenes. UPLC\u2010ESI\u2010MS and MS\n                    <sup>2<\/sup>\n                    Search of Related Metabolites from\n                    <i>Donella ubanguiensis<\/i>"],"prefix":"10.1002","volume":"28","author":[{"given":"Louis P.","family":"Sandjo","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina, Campus Universit\u00e1rio \u2013 Trindade  Florian\u00f3polis 88040\u2010970 SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus V.P. dos Santos","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences Universidade Federal de Santa Catarina, Campus Universit\u00e1rio \u2013 Trindade  Florian\u00f3polis 88040\u2010970 SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layzon A.L.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina, Campus Universit\u00e1rio \u2013 Trindade  Florian\u00f3polis 88040\u2010970 SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio C.M.","family":"Munhoz","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences Universidade Federal de Santa Catarina, Campus Universit\u00e1rio \u2013 Trindade  Florian\u00f3polis 88040\u2010970 SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz A.E.","family":"Pollo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina, Campus Universit\u00e1rio \u2013 Trindade  Florian\u00f3polis 88040\u2010970 SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maique W.","family":"Biavatti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina, Campus Universit\u00e1rio \u2013 Trindade  Florian\u00f3polis 88040\u2010970 SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonaventure T.","family":"Ngadjui","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Science University of Yaound\u00e9 1  P.O. 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