{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:10:26Z","timestamp":1788999026439,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Investigation on ganoderic acids (GAs) from different cultivars and origins of\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      species, regarding to their composition, contents and bioactivities, will be of great importance for the development and quality control of\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      \u2010based healthcare products or drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Comparative and chemometric analysis of different\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      species were conducted to reveal the correlations between their chemical fingerprints and anti\u2010proliferative activities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Six\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      samples with different origins and parts of fruiting body (pileus and stipe) were extracted with chloroform and enriched by a SPE\u2010C18 cartridge. The eluents were used for high\u2010performance liquid chromatography ultraviolet electrospray ionisation tandem mass spectrometry (HPLC\u2010UV\/ESI\u2010MS\/MS) analysis and cytotoxicity assay with three cancer cell lines (SGC\u20107901, HT\u201029 and Hep G2). Chemometric analysis was applied to correlate their chemical compositions and corresponding bioactivities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen peaks (accounting for 70% of the total peak areas) were identified as GAs, and their contents ranged from 0.368\u00a0to 10.8\u00a0\u03bcg\/g in various\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      species. The extracts from three\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      species had significant anti\u2010proliferative activities (inhibitory rates ranged from 70.8% to 80.7%), and extracts from Lurongzhi showed remarkable inhibition to all three cancer cells (inhibitory rates range from 81.6% to 92.1%). Finally, chemometric analysis revealed that 3,7,12\u2010trihydroxy\u20104,4,14\u2010trimethyl\u201011,15\u2010dioxochol\u20108\u2010en\u201024\u2010oic acid and 12\u2010acetoxy\u201015\u2010hydroxy\u20104,4,14\u2010trimethyl\u20103,7,11\u2010trioxochol\u20108\u2010en\u201024\u2010oic acid were the two compounds with most potential anti\u2010proliferative activity for SGC\u20107901.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The correlations between chemical fingerprints and anti\u2010proliferative activities of various\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      species give remarkable insight into the true bioactive components of chemical markers for the quality assessment of the\n                      <jats:italic>Ganoderma<\/jats:italic>\n                      resources, and provide a good guidance for the study on the chemical spectrum\u2013bioactivity relationship.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.2830","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T05:16:44Z","timestamp":1554095804000},"page":"474-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparative and chemometric analysis of correlations between the chemical fingerprints and anti\u2010proliferative activities of ganoderic acids from three\n                    <i>Ganoderma<\/i>\n                    species"],"prefix":"10.1002","volume":"30","author":[{"given":"Chunyun","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences  Wuhan China"},{"name":"The Sino\u2010Africa Joint Research Centre, Chinese Academy of 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