{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:18:18Z","timestamp":1761164298021,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Previous studies report the isolation mainly of terthiophene derivatives and flavonoids from\n                      <jats:italic>Dyssodia<\/jats:italic>\n                      species. Terthiophenes are known as photosensitizers by their capacity to generate singlet oxygen (\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ), and flavonoid antioxidant activity is recognized. These opposite properties could represent interesting options in photodynamic therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine the antioxidant and photosensitizer activities of extracts and isolates of\n                      <jats:italic>Dyssodia pinnata<\/jats:italic>\n                      by electron paramagnetic resonance (EPR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Extracts and isolates were evaluated as antioxidants by the interactions with copper ion (Cu\n                      <jats:sup>2+<\/jats:sup>\n                      ) observed in EPR, and by the 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl radical (DPPH) and the thiobarbituric reactive substances (TBARS) methods. Their abilities as\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      producers were also estimated by EPR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Terthiophenes were obtained from hexane (DPH) and acetone (DPA) extracts, and flavonoids from DPA and methanol (DPM) extracts. The interaction with Cu\n                      <jats:sup>2+<\/jats:sup>\n                      of extracts and isolated compounds of\n                      <jats:italic>Dyssodia pinnata<\/jats:italic>\n                      showed two effects in EPR: reduction and chelation; flavonoids exhibited both effects, while terthiophenes showed only reduction. DPA, DPM, and flavonoids were active in DPPH and TBARS assays. Quercetagetin\u20107\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010glucoside showed the highest antioxidant and chelating activities, 3\u2010glycosidated flavonoids were less active. Upon irradiation extracts and terthiophenes induced\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      formation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Flavonoid reducing activity on Cu\n                      <jats:sup>2+<\/jats:sup>\n                      and free radical scavenging capacity were related to the number of hydroxy groups and to the conjugation between the B and C rings. All tested flavonols showed a major complex with Cu\n                      <jats:sup>2+<\/jats:sup>\n                      , with the most probable site of chelation between the 5\u2010hydroxy and 4\u2010oxo groups. Extracts and terthiophene derivatives showed photosensitizer activity. Thus, EPR is useful to evaluate free radical scavenging and pro\u2010oxidant properties.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.2889","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T08:38:10Z","timestamp":1566376690000},"page":"252-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recognition of antioxidants and photosensitizers in\n                    <i>Dyssodia pinnata<\/i>\n                    by EPR spectroscopy"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-3525","authenticated-orcid":false,"given":"Amira","family":"Arciniegas","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria  Coyoac\u00e1n 04510 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-7085","authenticated-orcid":false,"given":"Virginia","family":"G\u00f3mez\u2010Vidales","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria  Coyoac\u00e1n 04510 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-7136","authenticated-orcid":false,"given":"Ana\u2010L.","family":"P\u00e9rez\u2010Castorena","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria  Coyoac\u00e1n 04510 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-6017","authenticated-orcid":false,"given":"Antonio","family":"Nieto\u2010Camacho","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria  Coyoac\u00e1n 04510 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-8548","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Villase\u00f1or","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria  Coyoac\u00e1n 04510 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0250-0757","authenticated-orcid":false,"given":"Alfonso","family":"Romo de Vivar","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria  Coyoac\u00e1n 04510 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"769","volume-title":"The Biology and Chemistry of Compositae","author":"Strother JL","year":"1977"},{"key":"e_1_2_5_3_1","first-page":"371","article-title":"Renovation of Dyssodia (Compositae: Tageteae)","volume":"11","author":"Strother JL","year":"1986","journal-title":"SIDA"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1016\/0031-9422(76)85098-4"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1002\/cber.19761090312"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1016\/0031-9422(79)80096-5"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1002\/cbdv.201700415"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1021\/jf9701502"},{"unstructured":"AguilarA CamachoJR ChinS J\u00e1cquezP L\u00f3pezME.Herbario Medicinal del Instituto Mexicano del Seguro Social. 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