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However, current quality identification of LWDHP mainly relies on a thin\u2010layer chromatography (TLC) method that is complicated and deficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study is to simplify the identification process and provide a more comprehensive quality assessment method of LWDHP by developing an integrated strategy based on liquid chromatography coupled with mass spectrometry (LC\u2010MS) and multivariate statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole\u2010time of flight mass spectrometry (UHPLC\/QTOF\u2010MS) was employed to perform qualitative analyses of a home\u2010made LWDHP and to establish a stably characteristic compound library by analysis of batches of its component herbs. Then selective ion monitoring (SIM) of single MS was utilised to develop a rapid identification method based on the UHPLC\/QTOF\u2010MS analysis result. Multivariate statistical analysis was subsequently used for the quality assessment of different commercial samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010eight characteristic compounds were characterised, and 68 of them were recorded to establish a stably characteristic compound library. Thirty\u2010one compounds were selected from the library for the establishment of SIM identification method. Good specificity, capability, and feasibility had been respectively verified by the analysis of blank sample, negative control (NC) preparation samples, home\u2010made LWDHP sample, and commercial sample. Multivariate statistical analysis of 20 batches of commercial LWDHP samples revealed the quality consistency of the same vendor's product and quality difference between diverse vendors' products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SIM identification method by a single analysis could significantly simplify the identification process of LWDHP, and it was performed in a holistic mode for no less than two compounds of each component herb monitored. Moreover, it could also be combined with multivariate statistical analysis to conduct quality assessments of batches of samples. The integrated strategy used in the study of LWDHP could be applied for the identification of other CPM as well.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.2927","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T15:20:45Z","timestamp":1583335245000},"page":"183-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An integrated strategy for holistic quality identification of Chinese patent medicine:\n                    <i>Liuwei Dihuang Pills<\/i>\n                    as a case study"],"prefix":"10.1002","volume":"32","author":[{"given":"Xia","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  501 Haike Road Shanghai 201203 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