{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:50:50Z","timestamp":1784771450141,"version":"3.55.0"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U19A2034"],"award-info":[{"award-number":["U19A2034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Widespread use of antibiotics has led to an increase in bacterial multiple drug resistance, thereby searching for natural antimicrobial agents from plants becomes an effective and alternative approach. In the present study, we selected six foodborne bacteria to evaluate the antibacterial activities of 12 medicinal plants ethyl acetate (EA) extracts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to search for natural antibiotic substitutes from plant extracts. The antibacterial components were further discussed through chemometric and mass spectroscopic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Agar well diffusion and the microdilution methods were used to test the antibacterial activity. Total phenolic content (TPC) and total flavonoid content (TFC) were used to judge the active phytochemicals. To further characterise the potential antibacterial components, an ultra\u2010performance liquid chromatography\u2010quadrupole\u2010time of flight\u2010mass spectrometry (UPLC\u2010Q\u2010TOF\u2010MS) coupled with Pearson correlation and feature\u2010based molecular network (FBMN) were proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of the plant extracts possessed antibacterial activity against <jats:styled-content style=\"fixed-case\"><jats:italic>Bacillus subtilis<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>Salmonella typhi<\/jats:italic><\/jats:styled-content>. <jats:italic>Toona sinensis<\/jats:italic> shoots and <jats:styled-content style=\"fixed-case\"><jats:italic>Firmiana simplex<\/jats:italic><\/jats:styled-content> barks showed high inhibitory activities against <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content>, <jats:styled-content style=\"fixed-case\"><jats:italic>Shigella dysenteriae<\/jats:italic><\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> strains with minimum inhibitory concentrations (MICs) of 1.56, 0.78, and 0.39\u2009mg\/mL, respectively. <jats:styled-content style=\"fixed-case\"><jats:italic>Salmonella typhi<\/jats:italic><\/jats:styled-content> was highly sensitive to <jats:styled-content style=\"fixed-case\"><jats:italic>Firmiana simplex<\/jats:italic><\/jats:styled-content> barks with an inhibitory diameter up to 21.67\u2009\u00b1\u20090.95\u2009mm, and MIC at 0.78\u2009mg\/mL. Moreover, <jats:italic>Toona sinensis<\/jats:italic> shoots and <jats:styled-content style=\"fixed-case\"><jats:italic>Firmiana simplex<\/jats:italic><\/jats:styled-content> barks had the highest TPCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicated that <jats:italic>Toona sinensis<\/jats:italic> shoots, <jats:italic>Koelreuteria paniculate<\/jats:italic> seeds, and <jats:styled-content style=\"fixed-case\"><jats:italic>Firmiana simplex<\/jats:italic><\/jats:styled-content> barks could be supplied as potential sources of antimicrobial agents. Furthermore, 36 potential bioactive compounds were identified mainly as polyphenols, glycosides, and terpenoids.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pca.3103","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T18:44:45Z","timestamp":1642531485000},"page":"473-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Chemical composition and antibacterial activity of 12 medicinal plant ethyl acetate extracts using LC\u2013MS feature\u2010based molecular networking"],"prefix":"10.1002","volume":"33","author":[{"given":"Zi","family":"Yang","sequence":"first","affiliation":[{"name":"Natural Products Laboratory, State Key Laboratory of Tea Plant Biology and Utilisation Anhui Agricultural University  Hefei P. R. 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