{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:08:57Z","timestamp":1785496137222,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Centrifugal partition chromatography (CPC) is a liquid\u2013liquid chromatography characterised by its solvent flexibility. The compounds undergoing separation are subjected to a continuous partition process between two immiscible phases in a column space free of solid support. In the context of green chemistry, it is important to substitute halogenated and petroleum\u2010based solvents commonly used in purification processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The main goal of the current study was to replace classical solvents used in CPC (e.g., hexane and methanol) by green and renewable alternatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Solvents were first selected based on literature. Their commercial availability, price, recyclability, toxicity and ability to form two phases were particularly sought after.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>The new two\u2010phase solvent systems were evaluated for the purification of two compounds of interest: piperine and cannabidiol. Using these alternative two\u2010phase solvent systems allows us to isolate natural products with a high purity level (&gt; 95%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Substituting petroleum\u2010based solvents with bio\u2010sourced, renewable alternatives reduces the environmental impact of CPC. Herein, new biphasic solvent systems were built using hexamethyldisiloxane, ethyl isobutyrate and 2\u2010methyl tetrahydrofuran in combination with ethanol and water. Furthermore, this research provides a scientific basis for developing new and sustainable solvent systems in CPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.3298","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:46:52Z","timestamp":1698108412000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of alternative two\u2010phase solvent systems for purification of natural products by centrifugal partition chromatography"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-9875","authenticated-orcid":false,"given":"Thomas","family":"Michel","sequence":"first","affiliation":[{"name":"GILSON Purification SAS  Saint\u2010Av\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lestine","family":"Loyet","sequence":"additional","affiliation":[{"name":"GILSON Purification SAS  Saint\u2010Av\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Boulho","sequence":"additional","affiliation":[{"name":"GILSON Purification SAS  Saint\u2010Av\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Eveno","sequence":"additional","affiliation":[{"name":"GILSON Purification SAS  Saint\u2010Av\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Audo","sequence":"additional","affiliation":[{"name":"GILSON Purification SAS  Saint\u2010Av\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.10.044"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010013\u20107017\u20108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np501065h"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9002547"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac4002854"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119740117.ch7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.1c01628"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2016.01.024"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2023.123271"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116108"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.11.083"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2020.100027"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.07.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12246"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.33140\/JCERP\/01\/01\/00001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40508\u2010016\u20100051\u2010z"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10098\u2010021\u201002188\u20108"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60241a"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5GC01008J"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.12.044"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01496390902775877"},{"key":"e_1_2_6_23_1","unstructured":"Gilson Purification.CPC 250: mass\u2010directed purification of piperine fromPiper nigrum. Technical Note TN208.https:\/\/www.analiticaweb.com.br\/downloads\/literaturas\/purificacao-piperina-cpc-250-ms.pdf"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116554"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1081\/JLC\u2010200028170"},{"key":"e_1_2_6_26_1","first-page":"S37","article-title":"Centrifugal partition chromatography for purification of cannabidiol from Cannabis sativa","volume":"40","author":"Lahoutifard\u2010Henry N","year":"2019","journal-title":"Z Phytother"},{"key":"e_1_2_6_27_1","unstructured":"Gilson Purification.Single step purification of THC CBD CBN CBG and minor cannabinoids by centrifugal partition chromatography (CPC). Application Note AN1036.https:\/\/www.gilson.com\/pub\/media\/docs\/AN1036-SINGLE-STEP-PURIFICATION-OF-THC.pdf"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.3298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:18:19Z","timestamp":1761067099000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.3298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/pca.3298"],"URL":"https:\/\/doi.org\/10.1002\/pca.3298","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]},"assertion":[{"value":"2023-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}