{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:07:11Z","timestamp":1767211631653,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n The active compound (\n E<\/jats:italic>\n )\u20101\u2010(3\u2032,4\u2032\u2010dimethoxyphenyl)butadiene (DMPBD) isolated from the rhizomes of\n \n Zingiber cassumunar<\/jats:italic>\n <\/jats:styled-content>\n Roxb. has potent anti\u2010inflammatory and anticancer activities. Although DMPBD is one of the promising drug candidates for phytomedicine, its limited stability impedes its widespread use. For the development of new drugs, the assessment of their chemical stability is essential, ensuring they maintain their properties within specified limits throughout the period from production until use.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n In the present study, we aimed to evaluate the stability of DMPBD under various conditions, including different solvents, temperatures, and lighting conditions, to identify the factors affecting stability and optimize the storage and handling conditions.<\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n \n DMPBD samples subjected to the different conditions tested were monitored by quantitative\n 1<\/jats:sup>\n H NMR (qHNMR), using an internal standard for the determination of the absolute quantity of DMPBD as a function of time and the changes thereof within 1\u00a0month.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Significant decomposition of DMPBD was observed in chloroform\u2010\n d<\/jats:italic>\n 1<\/jats:sub>\n , whereas its content remained constant in methanol\u2010\n d<\/jats:italic>\n 4<\/jats:sub>\n . The content of DMPBD was maintained upon storage at temperatures below 4\u00b0C, both as methanolic solution and in the crude extract. Exposure to light had a slight negative impact on its contents. Some degradation products could be identified as resulting from O\n 2<\/jats:sub>\n \u2010induced cleavage of the diene moiety.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n For pharmacological\/therapeutic applications, DMPBD should be stored in the form of the crude extract or as a purified material in methanolic solution. Ideally, the storage temperature should be below 4\u00b0C and O\n 2<\/jats:sub>\n should be excluded.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pca.3314","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T03:06:42Z","timestamp":1703214402000},"page":"579-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NMR\u2010based stability evaluation of (\n E<\/i>\n )\u20101\u2010(3\u2032,4\u2032\u2010dimethoxyphenyl)butadiene (DMPBD) from\n \n Zingiber cassumunar<\/i>\n <\/scp>\n Roxb. rhizome"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-9655","authenticated-orcid":false,"given":"Boonwiset","family":"Seaho","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Technology Thammasat University (Rangsit Campus) Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatkamon","family":"Lekwongphaiboon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Technology Thammasat University (Rangsit Campus) Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wichayasith","family":"Inthakusol","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Center, Office of Advanced Science and Technology Thammasat University (Rangsit Campus) Pathum Thani Thailand"},{"name":"Thammasat University Research Unit in Cannabis and Herbal Products Innovation Thammasat University (Rangsit Campus) Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saisuree","family":"Prateeptongkum","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Technology Thammasat University (Rangsit Campus) Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wacharee","family":"Harnying","sequence":"additional","affiliation":[{"name":"Department of Chemistry (Organic Chemistry) University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Berkessel","sequence":"additional","affiliation":[{"name":"Department of Chemistry (Organic Chemistry) University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-6581","authenticated-orcid":false,"given":"Nongnaphat","family":"Duangdee","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Center, Office of Advanced Science and Technology Thammasat University (Rangsit Campus) Pathum Thani Thailand"},{"name":"Thammasat University Research Unit in Cannabis and Herbal Products Innovation Thammasat University (Rangsit Campus) Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1572\u20105995(00)80142\u20108"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Ethnobotany, phytochemistry and pharmacology of Zingiber cassumunar Roxb. (Zingiberaceae)","volume":"4","author":"Singh CB","year":"2015","journal-title":"J Pharmacogn Phytochemistry"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2017.09.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082377"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/app112110205"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.14456\/2022s10101"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH9790071"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.28.2948"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(81)83058\u20100"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031\u20109422(00)94994\u2010x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102004\u2010832656"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.57.1267"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20108741(03)00098\u2010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.53.1466"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.59.365"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4661"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR12.360"},{"key":"e_1_2_6_20_1","unstructured":"World Health Organization.Pharmaceuticals unit. WHO guidelines on stability testing of pharmaceutical products containing well\u2010established drug substances in conventional dosage forms. 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