{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:51:05Z","timestamp":1776199865415,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2023zd008"],"award-info":[{"award-number":["2023zd008"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFS0624"],"award-info":[{"award-number":["2022YFS0624"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023NSFSC0614"],"award-info":[{"award-number":["2023NSFSC0614"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Liuweizhiji Gegen\u2010Sangshen (LGS) oral liquid is a Chinese patent medicine that is widely used for the prevention and treatment of alcoholic liver disease in clinical practice. However, the chemical complexity of LGS has not yet been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to rapidly identify chemical constituents of LGS and establish a quality control method based on fingerprint and quantitative analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A comprehensive strategy was used by combining qualitative analysis by ultra\u2010performance liquid chromatography tandem quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\u2010Q\u2010TOF\u2010MS) and fingerprint analysis by high\u2010performance liquid chromatography with diode array detection (HPLC\u2010DAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 162 chemical components in LGS, including 91 flavonoids, 31 organic acids, and 20 phenolic compounds, were identified or preliminarily characterized in both positive and negative ion modes based on the UPLC\u2010Q\u2010TOF\u2010MS results. Of these, 37 were confirmed with the reference standards. In fingerprint analysis, 23 peaks were chosen as common peaks and used to evaluate the similarity of different batches of LGS. Subsequently, a rapid quantification method was optimized and validated for the simultaneous determination of multiple chemical markers in LGS. The validated quantitative method was successfully used to analyze different batches of LGS samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed comprehensive strategy combining HPLC\u2010DAD fingerprinting and multi\u2010component quantification demonstrated satisfactory results with high efficiency, accuracy, and reliability. This can be used as a reference for the overall quality consistency evaluation of Chinese patent medicines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.3333","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T02:56:04Z","timestamp":1708052164000},"page":"860-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chemical profiling and quality evaluation of Liuweizhiji Gegen\u2010Sangshen oral liquid by UPLC\u2010Q\u2010TOF\u2010MS and HPLC\u2010diode array detector fingerprinting"],"prefix":"10.1002","volume":"35","author":[{"given":"Shulin","family":"Wei","sequence":"first","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gerontology The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Li","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiangang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueshui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukuan","family":"Du","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Deng","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"},{"name":"The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-0076","authenticated-orcid":false,"given":"Xu","family":"Wu","sequence":"additional","affiliation":[{"name":"Cell Therapy &amp; Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"South Sichuan Institute of Translational Medicine  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/638197"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.13863\/j.issn1001\u20104454.2018.09.044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111121"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008\u20100805.2020.05.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2020.10.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111401"},{"key":"e_1_2_6_9_1","volume-title":"Pharmacopoeia of the People's Republic of China","author":"Commission CP","year":"2020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2022.08.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2021.09.008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2021.06.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2020.11.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126568"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120329"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2022.08.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462178"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.09.038"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065\u2010023\u201000920\u20107"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1875\u20105364(13)60069\u20102"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf803693t"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1067089"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10337\u2010019\u201003806\u2010w"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.03.008"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202100240"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463342"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1875\u20105364(23)60399\u20101"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.256"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010022\u201000666\u20109"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154589"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.03.008"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111927"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010023\u201000845\u20100"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.3333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:40:22Z","timestamp":1761064822000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.3333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/pca.3333"],"URL":"https:\/\/doi.org\/10.1002\/pca.3333","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}