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Network pharmacology research methods were employed to investigate the potential mechanisms of action of the identified components in the treatment of major clinical diseases. Subsequently, a combination of HPLC chromatographic fingerprinting for qualitative analysis and multi\u2010index content determination was used to evaluate the detectability of the identified quality markers (Q\u2010markers).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six prototype components were tentatively characterized in rat serum. Network pharmacology analysis showed six effective components, namely 7\u2010hydroxycoumarin, isoscopoletin, diosmin, hesperidin, 5,7\u2010dimethoxycoumarin, and bergapten, which played important roles in the treatment of chronic gastritis, functional dyspepsia, peptic ulcer, and depression and were preliminarily identified as Q\u2010markers. The results of content determination in 15 batches of CSF indicated significant differences in the content of medicinal materials from different origins. However, compared with the preliminarily determined Q\u2010markers, all six components could be measured and were determined as Q\u2010markers of CSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The chemical Q\u2010markers obtained in this study could be used for effective quality control of CSF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pca.3337","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T22:54:47Z","timestamp":1708296887000},"page":"1017-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quality assessment and Q\u2010markers discovery in Citri Sarcodactylis Fructus by integrating serum pharmacochemistry and network pharmacology"],"prefix":"10.1002","volume":"35","author":[{"given":"Yuxin","family":"Li","sequence":"first","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Irradiation Preservation Key Laboratory of Sichuan Province Sichuan Institute of Atomic Energy  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingchuan","family":"Pan","sequence":"additional","affiliation":[{"name":"Irradiation Preservation Key Laboratory of Sichuan Province Sichuan Institute of Atomic Energy  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-3952","authenticated-orcid":false,"given":"Hezhong","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.3069"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00854"},{"key":"e_1_2_7_4_1","volume-title":"Chinese Pharmacopoeia (Part 1). 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