{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:11:23Z","timestamp":1778775083572,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018685","name":"Shanxi Province Foundation for Returness","doi-asserted-by":"publisher","award":["20210013"],"award-info":[{"award-number":["20210013"]}],"id":[{"id":"10.13039\/501100018685","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017949","name":"Health Commission of Shanxi Province","doi-asserted-by":"publisher","award":["2020XM12"],"award-info":[{"award-number":["2020XM12"]}],"id":[{"id":"10.13039\/100017949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gomisin is a natural dibenzo cyclooctene lignan, which is mainly derived from the family Magnoliaceae. It has anti\u2010inflammatory, antioxidant, anti\u2010tumor, anti\u2010aging, and hypoglycemic effects. Gomisins play important roles as medicines, nutraceuticals, food additives, and cosmetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to establish a micellar electrokinetic chromatography (MEKC) method for simultaneous separation and determination of seven biphenyl cyclooctene lignans (Gomisin D, E, G, H, J, N, and O) in <jats:italic>Schisandra chinensis<\/jats:italic> and its preparations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The method was optimized by studying the effects of the main parameters on the separation. The method has been validated and successfully applied to the determination of seven Gomisins in <jats:italic>S.\u00a0chinensis<\/jats:italic> and its preparations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the separation system, the running buffer was composed of 20\u2009mM Na<jats:sub>2<\/jats:sub>HPO<jats:sub>4<\/jats:sub>, 8.0\u2009mM sodium dodecyl sulfate (SDS), 11% (v\/v) methanol, and 6.0% (v\/v) ethanol. A diode array detector was used with a detection wavelength of 230\u2009nm, a separation voltage of 17\u2009kV, and an operating temperature of 25\u00b0C. Under this condition, the seven analytes were separated at baseline within 20\u2009min, and a good linear relationship was obtained with correlation coefficient ranging from 0.9919 to 0.9992. The limit of detection (LOD, S\/N\u2009=\u20093) and the limit of quantification (LOQ, S\/N\u2009=\u200910) ranged from 0.8 to 0.9\u00a0\u03bcg\/mL and from 2.6 to 3.0\u00a0\u03bcg\/mL, respectively. The recovery rate was between 99.1% and 102.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The experimental results indicated that this method is suitable for the separation and determination of seven <jats:italic>Schisandra<\/jats:italic> biphenyl cyclooctene lignan compounds in real samples. At the same time, it provides an effective reference for the quality control of <jats:italic>S.\u00a0chinensis<\/jats:italic> and its preparations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pca.3349","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T04:55:09Z","timestamp":1711947309000},"page":"1142-1151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simultaneous separation and determination of seven biphenyl cyclooctene lignans in <i>Schisandra chinensis<\/i> and its preparations by micellar electrokinetic chromatography with dual organic solvent system"],"prefix":"10.1002","volume":"35","author":[{"given":"Meiyi","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmacy Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzhao","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruimiao","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Yu","sequence":"additional","affiliation":[{"name":"Translational Medicine Research Center Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0394-8692","authenticated-orcid":false,"given":"Anjia","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11240\u2010010\u20109740\u20106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010016\u20109470\u20104"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(01)00556\u20108"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123639"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12524"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113406"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2017.235"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2018.054"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.162"},{"issue":"1","key":"e_1_2_6_11_1","first-page":"711","article-title":"Anticancer activity of gomisin J from Schisandra chinensis fruit","volume":"41","author":"Samil J","year":"2019","journal-title":"Oncol Rep"},{"key":"e_1_2_6_12_1","unstructured":"SunH ZhangJL WangJ et al.Use of Gomisin E in the preparation of drugs for cardiovascular disease. 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