{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:22:12Z","timestamp":1788664932792,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n In the last few decades, nanoparticles have found extensive use in a variety of biological applications. Traditional medicine widely uses\n Acanthophora<\/jats:italic>\n sp., a marine macroalgae, to cure and prevent diabetes, skin disorders, and blood clotting.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The present study aims to investigate whether green\u2010synthesized copper nanoparticles (CuNPs) might work as an anticoagulant.<\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n \n The CuNPs were made using an environmentally friendly method that uses\n Acanthophora<\/jats:italic>\n extract. We used UV\u2010vis spectroscopy to assess the surface plasmon resonance of the material, scanning electron microscopy (SEM) to analyze its form, and energy dispersive X\u2010ray (EDX) spectroscopy to identify the material's constituent elements. Furthermore, Fourier\u2010transform infrared (FT\u2010IR) determined the functional groups of the CuNPs.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The biosynthesis of CuNPs was confirmed by UV\u2010vis spectroscopy, which showed a surface plasmon resonance peak at 570\u2009nm. The FT\u2010IR analysis showed that certain functional groups are involved in the formation of CuNPs. These groups include OH stretching, C=O stretching, C\u2010H bonding, C\u2010N bonding, and Cu vibration. SEM analysis demonstrated the morphology of CuNPs synthesized, with a size of 0.5\u00a0\u03bcm, while EDS analysis confirmed their purity. The anticoagulant activity of prothrombin time (PT) and activated partial thromboplastin time (aPTT) assays showed that the clotting time got longer depending on the concentration. The CuNPs synthesized from\n Acanthophora<\/jats:italic>\n had strong anticoagulant effects at 100\u2009\u03bcg\/mL, further suggesting that they might be useful as a natural blood thinner.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The interesting thing we observed is that the green\u2010synthesized CuNPs made from\n Acanthophora<\/jats:italic>\n extract could be used in anticoagulation therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pca.3384","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:35:15Z","timestamp":1716165315000},"page":"2228-2235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Biosynthesis, characterization, and anticoagulant properties of copper nanoparticles from red seaweed of\n Acanthophora<\/i>\n sp."],"prefix":"10.1002","volume":"36","author":[{"given":"Jayaharini","family":"Krishnaswamy","sequence":"first","affiliation":[{"name":"Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences Saveetha University Thandalam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Christupaul Roseline","sequence":"additional","affiliation":[{"name":"Marine Biomedical Research Lab & Environmental Toxicology Unit, Cellular and Molecular Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai Tamil Nadu India"},{"name":"Centre for Marine and Aquatic Research (CMAR), Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamala","family":"Kannan","sequence":"additional","affiliation":[{"name":"Centre for Marine and Aquatic Research (CMAR), 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